Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma.

Authors

Cook PJ Peter J , Thomas R Rozario , Kingsley PJ Philip J , Shimizu F Fumiko , Montrose DC David C , Marnett LJ Lawrence J , Tabar VS Viviane S , Dannenberg AJ Andrew J , Benezra R Robert .
Neuro-oncology. 2016 3 ; ().

Abstract

In glioblastoma (GBM), Id1 serves as a functional marker for self-renewing cancer stem-like cells. We investigated the mechanism by which cyclooxygenase-2 (Cox-2)-derived prostaglandin E2 (PGE2) induces Id1 and increases GBM self-renewal and radiation resistance.