Publications

2024

2023

Uddin MJ, Niitsu H, Coffey RJ, Marnett LJ, Development of Pluoronic nanoparticles of fluorocoxib A for endoscopic fluorescence imaging of colonic adenomas Journal of biomedical optics. 2023 Apr 20; 28 (4) 040501
Morrison VE, Houpert MG, Trapani JB, Brockman AA, Kingsley PJ, Katdare KA, Layden HM, Nguena-Jones G, Trevisan AJ, Maguire-Zeiss KA, Marnett LJ, Bixa GJ, Ihrie RA, Carter BD, Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone bioRxiv : the preprint server for biology. 2023 Mar 6;
Aleem AM, Kang W, Lin S, Milad M, Kingsley PJ, Crews BC, Uddin MJ, Rouzer CA, Marnett LJ, Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages ACS chemical biology. 2023 Jan 13;

2022

Uddin MJ, Lo JH, Oltman CG, Crews BC, Huda T, Liu J, Kingsley PJ, Lin S, Milad M, Aleem AM, Asaduzzaman A, McIntyre JO, Duvall CL, Marnett LJ, Discovery of a Redox-Activatable Chemical Probe for Detection of Cyclooxygenase-2 in Cells and Animals ACS chemical biology. 2022 Jul 5;
Haney M, Bedi G, Cooper ZD, Herrmann ES, Reed SC, Foltin RW, Kingsley PJ, Marnett LJ, Patel S, Impact of cyclooxygenase-2 inhibition on cannabis withdrawal and circulating endocannabinoids in daily cannabis smokers Addiction biology. 2022 Jul 2; 27 (4) e13183
Hu M, Zhu D, Zhang J, Gao F, Hashem J, Kingsley P, Marnett LJ, Mackie K, Chen C, Enhancing endocannabinoid signalling in astrocytes promotes recovery from traumatic brain injury Brain : a journal of neurology. 2022 Mar 11; 145 (1) 179-193
Zimmermann A, Vu O, Brüser A, Sliwoski G, Marnett LJ, Meiler J, Schöneberg T, Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y ChemMedChem. 2022 Jan 28; 17 (7) e202100683
Smalling RV, Bechard ME, Duryea J, Kingsley PJ, Roberts ER, Marnett LJ, Bilbao D, Stauffer SR, McDonald OG, Aminopyridine analogs selectively target metastatic pancreatic cancer Oncogene. 2022 Jan 14; 41 (10) 1518-1525

2021

Christov PP, Richie-Jannetta R, Kingsley PJ, Vemulapalli A, Kim K, Sulikowski GA, Rizzo CJ, Ketkar A, Eoff RL, Rouzer CA, Marnett LJ, Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-MdG, the Genomic Metabolite of MdG, and Liquid Chromatography-Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι Chemical research in toxicology. 2021 Dec 3;
Farrell JS, Colangeli R, Dong A, George AG, Addo-Osafo K, Kingsley PJ, Morena M, Wolff MD, Dudok B, He K, Patrick TA, Sharkey KA, Patel S, Marnett LJ, Hill MN, Li Y, Teskey GC, Soltesz I, In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity Neuron. 2021 Aug 21; 109 (15) 2398-2403.e4
Winters ND, Bedse G, Astafyev AA, Patrick TA, Altemus M, Morgan AJ, Mukerjee S, Johnson KD, Mahajan VR, Uddin MJ, Kingsley PJ, Centanni SW, Siciliano CA, Samuels DC, Marnett LJ, Winder DG, Patel S, Targeting diacylglycerol lipase reduces alcohol consumption in preclinical models The Journal of clinical investigation. 2021 Jul 22;

2020

Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E, Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa Gut. 2020 Jul 8;
Cekanova M, Pandey S, Olin S, Ryan P, Stokes JE, Hecht S, Martin-Jimenez T, Uddin MJ, Marnett LJ, Pharmacokinetic characterization of fluorocoxib D, a cyclooxygenase-2-targeted optical imaging agent for detection of cancer Journal of biomedical optics. 2020 Aug 10; 25 (8)
Uddin MJ, Vemulapalli A, Niitsu H, Crews BC, Oltman CG, Kingsley PJ, Kavanaugh TE, Bedingfield SK, Mcintyre JO, Milad M, Aleem AM, Coffey RJ, Duvall CL, Marnett LJ, Molecular Imaging of Inflammation in Osteoarthritis Using a Water-Soluble Fluorocoxib ACS medicinal chemistry letters. 2020 Feb 24; 11 (10) 1875-1880
Uddin MJ, Xu S, Crews BC, Aleem AM, Ghebreselasie K, Banerjee S, Marnett LJ, Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors ACS medicinal chemistry letters. 2020 Feb 14; 11 (10) 1881-1885

2019

Malerba P, Crews BC, Ghebreselasie K, Daniel CK, Jashim E, Aleem AM, Salam RA, Marnett LJ, Uddin MJ, Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer ACS medicinal chemistry letters. 2019 Jul 24; 11 (10) 1837-1842
Kingsley PJ, Rouzer CA, Morgan AJ, Patel S, Marnett LJ, Aspects of Prostaglandin Glycerol Ester Biology Advances in experimental medicine and biology. 2019 Sep 28; 1161 77-88
Marnett LJ, Adventures with Bruce Ames and the Ames test Mutation research. 2019 Jul 4; 846 403070
Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR, IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain Science (New York, N.Y.). 2019 Jul 19; 365 (6450)
Shockley EM, Rouzer CA, Marnett LJ, Deeds EJ, Lopez CF, Signal integration and information transfer in an allosterically regulated network NPJ systems biology and applications. 2019 Jul 18; 5 23
Scilimati A, Ferorelli S, Iaselli MC, Miciaccia M, Pati ML, Fortuna CG, Aleem AM, Marnett LJ, Perrone MG, Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection European journal of medicinal chemistry. 2019 Jun 15; 179 16-25
Uddin MJ, Wilson AJ, Crews BC, Malerba P, Uddin MI, Kingsley PJ, Ghebreselasie K, Daniel CK, Nickels ML, Tantawy MN, Jashim E, Manning HC, Khabele D, Marnett LJ, Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer ACS omega. 2019 May 24; 4 (5) 9251-9261
Xu S, Uddin MJ, Banerjee S, Duggan K, Musee J, Kiefer JR, Ghebreselasie K, Rouzer CA, Marnett LJ, Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site The Journal of biological chemistry. 2019 Apr 18; 294 (22) 8690-8698

2018

Wepy JA, Galligan JJ, Kingsley PJ, Xu S, Goodman MC, Tallman KA, Rouzer CA, Marnett LJ, Lysophospholipases Cooperate to Mediate Lipid Homeostasis and Lysophospholipid Signaling Journal of lipid research. 2018 Nov 27;
Liu Y, Ji L, Eno M, Kudalkar S, Li AL, Schimpgen M, Benchama O, Morales P, Xu S, Hurst D, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis DP, Zhou H, Honrao C, Mackie K, Reggio P, Hohmann AG, Marnett LJ, Makriyannis A, Nikas SP, ( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes Journal of medicinal chemistry. 2018 Sep 21; 61 (19) 8639-8657
Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ, Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 27;
Cavener VS, Gaulden A, Pennipede D, Jagasia P, Uddin J, Marnett LJ, Patel S, Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice Frontiers in neuroscience. 2018 Jul 31; 12 479
Morgan AJ, Kingsley PJ, Mitchener MM, Altemus M, Patrick TA, Gaulden AD, Marnett LJ, Patel S, Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain ACS Chemical Neuroscience. 2018 May 9;
Bedse G, Bluet RJ, Patrick TA, Romness KN, Gaulden AD, Kingsley PJ, Plath N, Marnett LJ, Patel S, Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors Translational Psychiatry. 2018 Apr 26; 8 (1)
Wauchope OR, Mitchener MM, Beavers WN, Galligan JJ, Camarillo JM, Sanders WD, Kingsley PJ, Shim HN, Blackwell T, Luong T, deCaestecker M, Fessel JP, Marnett LJ, Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA Nucleic acids research. 2018 Apr 20; 46 (7) 3458-3467
Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ, Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the … The Journal of biological chemistry. 2018 Jan 11;
Beeghly-Fadiel A, Wilson AJ, Keene S, El Ramahi M, Xu S, Marnett LJ, Fadare O, Crispens MA, Khabele D, Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors Journal of Ovarian Research. 2018 Feb 27; 17 (11 (1))

2017

Bedse G, Hartley ND, Neale E, Gaulden AD, Patrick TA, Kingsley PJ, Uddin MJ, Plath N, Marnett LJ, Patel S, Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxie… Biological psychiatry. 2017 Mar 15;
Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC, Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay and drug development technologies. 2017 Apr 15 (3) 113-119
Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S, Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. Nature communications. 2017 Mar 28; 8 14782
Aldrovandi M, Hinz C, Lauder SN, Podmore H, Hornshaw M, Slatter DA, Tyrrell VJ, Clark SR, Marnett LJ, Collins PW, Murphy RC, O'Donnell VB, DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil inte… Redox biology. 2017 Apr 11 663-672
Galligan JJ, Kingsley PJ, Wauchope OR, Mitchener MM, Camarillo JM, Wepy JA, Harris PS, Fritz KS, Marnett LJ, Quantitative Analysis and Discovery of Lysine and Arginine Modifications. Analytical chemistry. 2017 Jan 17; 89 (2) 1299-1306
Camarillo JM, Ullery JC, Rose KL, Marnett LJ, Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Lin… Chemical research in toxicology. 2017 Feb 20; 30 (2) 635-641
Galligan JJ, Marnett LJ, Histone Adduction and Its Functional Impact on Epigenetics. Chemical research in toxicology. 2017 Dec 17; 30 (1) 376-387
Beavers WN, Rose KL, Galligan JJ, Mitchener MM, Rouzer CA, Tallman KA, Lamberson CR, Wang X, Hill S, Ivanova PT, Brown HA, Zhang B, Porter NA, Marnett LJ, Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and T… ACS chemical biology. 2017 Jun 28;
Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T, Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6. Scientific reports. 2017 May 24; 7 (1) 2380

2016

Konkle ME, Blobaum AL, Moth CW, Prusakiewicz JJ, Xu S, Ghebreselasie K, Akingbade D, Jacobs AT, Rouzer CA, Lybrand TP, Marnett LJ, Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Ami… Biochemistry. 2016 Jan 19; 55 (2) 348-59
Camarillo JM, Rose KL, Galligan JJ, Xu S, Marnett LJ, Covalent modification of CDK2 by 4-hydroxynonenal as a mechanism of inhibition of cell cycle progres… Chemical Research in Toxicology. 2016 Feb 24;
Gamble-George JC, Baldi R, Halladay L, Kocharian A, Hartley N, Silva CG, Roberts H, Haymer A, Marnett LJ, Holmes A, Patel S, Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. eLife. 2016 5
Hinz C, Aldrovandi M, Uhlson C, Marnett LJ, Longhurst HJ, Warner TD, Alam S, Slatter DA, Lauder SN, Allen-Redpath K, Collins PW, Murphy RC, Thomas CP, O'Donnell VB, Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid… The Journal of Biological Chemistry. 2016 Apr 22;
Mont S, Davies SS, Roberts Second LJ, Mernaugh RL, McDonald WH, Segal BH, Zackert W, Kropski JA, Blackwell TS, Sekhar KR, Galligan JJ, Massion PP, Marnett LJ, Travis EL, Freeman ML, Accumulation of isolevuglandin-modified protein in normal and fibrotic lung. Scientific reports. 2016 6 24919
Uddin MJ, Werfel TA, Crews BC, Gupta MK, Kavanaugh TE, Kingsley PJ, Boyd K, Marnett LJ, Duvall CL, Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation… Biomaterials. 2016 Jun 92 71-80
Cook PJ, Thomas R, Kingsley PJ, Shimizu F, Montrose DC, Marnett LJ, Tabar VS, Dannenberg AJ, Benezra R, Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental gliob… Neuro-oncology. 2016 Mar
Kudalkar SN, Kingsley PJ, Marnett LJ, Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. Methods in molecular biology (Clifton, N.J.). 2016 1412 205-15
Adeniji A, Uddin MJ, Zang T, Tamae D, Wangtrakuldee P, Marnett LJ, Penning TM, , Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reduc… Journal of Medicinal Chemistry. 2016 Aug 16 (59) 7431-7444
Uddin MJ, Crews BC, Ghebreselasie K, Daniel CK, Kingsley PJ, Banerjee S, Marnett LJ, Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors ACS Chemical Biology. 2016 Sep 19;
Uddin MJ, Moore CE, Crews BC, Daniel CK, Ghebreselasie Kathleen L, McIntyre JO, Marnett LJ, Jayagopal A, Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovasculari… Journal of Biomedical Optics. 2016 Sep 1; 21 (9)
Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA, Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcin… Cancer prevention research (Philadelphia, Pa.). 2016 Nov 9 (11) 855-865
Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ, Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Depende… Neuron. 2016 Sep 21; 91 (6) 1244-52
Uddin MI, Evans SM, Craft JR, Capozzi ME, McCollum GW, Yang R, Marnett LJ, Uddin MJ, Jayagopal A, Penn JS, In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Scientific reports. 2016 Aug 5; 6 31011

2015

Uddin MI, Evans SM, Craft JR, Marnett LJ, Uddin MJ, Jayagopal A, Applications of azo-based probes for imaging retinal hypoxia. ACS medicinal chemistry letters. 2015 Apr 9; 6 (4) 445-9
Wauchope O, Beavers WN, Galligan JJ, Mitchener M, Kingsley PJ, Marnett LJ, Nuclear oxidation of a major peroxidation DNA adduct, M1dG, in the Genome. Chemical Research in Toxicology. 2015 Oct 15;
Wang JW, Woodward DF, Martos JL, Cornell CL, Carling RW, Kingsley PJ, Marnett LJ, Multitargeting of selected prostanoid receptors provides agents with enhanced anti-inflammatory acti… FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Sep 29;
Mitchener MM, Hermanson DJ, Shockley EM, Brown HA, Lindsley CW, Reese J, Rouzer CA, Lopez CF, Marnett LJ, Competition and allostery govern substrate selectivity of cyclooxygenase-2. Proceedings of the National Academy of Sciences of the United States of America. 2015 Oct 6; 112 (40) 12366-71
DeGuire SM, Earl DC, Du Y, Crews BA, Jacobs AT, Ustione A, Daniel C, Chong KM, Marnett LJ, Piston DW, Bachmann BO, Sulikowski GA, Fluorescent Probes of the Apoptolidins and their Utility in Cellular Localization Studies. Angewandte Chemie (International ed. in English). 2015 Jan 12; 54 (3) 961-4
Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, Essigmann JM, Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in v… Nucleic acids research. 2015 Apr 2;
Blobaum AL, Xu S, Rowlinson SW, Duggan KC, Banerjee S, Kudalkar SN, Birmingham WR, Ghebreselasie K, Marnett LJ, Action at a Distance: Mutations of Peripheral Residues Transform Rapid Reversible Inhibitors to Slow… The Journal of biological chemistry. 2015 Mar 30;
Ra H, González-González E, Uddin MJ, King BL, Lee A, Ali-Khan I, Marnett LJ, Tang JY, Contag CH, Detection of Non-Melanoma Skin Cancer by in vivo Fluorescence Imaging with Fluorocoxib A. Neoplasia (New York, N.Y.). 2015 Feb 17 (2) 201-7
Aluise CD, Camarillo JM, Shimozu Y, Galligan JJ, Rose KL, Tallman KA, Marnett LJ, Site-Specific, Intramolecular Cross-Linking of Pin1 Active Site Residues by the Lipid Electrophile 4… Chemical research in toxicology. 2015 Mar 18;
Kudalkar SN, Nikas SP, Kingsley PJ, Xu S, Galligan JJ, Rouzer CA, Banerjee S, Ji L, Eno MR, Makriyannis A, Marnett LJ, 13-methylarachidonic Acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclo… The Journal of biological chemistry. 2015 Mar 20; 290 (12) 7897-909
Neumann W, Xu S, Sárosi MB, Scholz MS, Crews BC, Ghebreselasie K, Banerjee S, Marnett LJ, Hey-Hawkins HC, nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2. ChemMedChem. 2015 Jun 18;
Wilson AJ, Fadare O, Beeghly-Fadiel A, Son DS, Liu Q, Zhao S, Saskowski J, Uddin MJ, Daniel C, Crews B, Lehmann BD, Pietenpol JA, Crispens MA, Marnett LJ, Khabele D, Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous … Oncotarget. 2015 May 4;
Uddin MJ, Crews BC, Ghebreselasie K, Daniel CK, Kingsley PJ, Xu S, Marnett LJ, Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe. Journal of biomedical optics. 2015 May 20 (5) 50502

2014

Derewacz DK, McNees CR, Scalmani G, Covington CL, Shanmugam G, Marnett LJ, Polavarapu PL, Bachmann BO, Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete. Journal of natural products. 2014 Jul 21;
Beavers WN, Serwa R, Shimozu Y, Tallman KA, Vaught M, Dalvie ED, Marnett LJ, Porter NA, ω-Alkynyl Lipid Surrogates for Polyunsaturated Fatty Acids: Free Radical and Enzymatic Oxidations. Journal of the American Chemical Society. 2014 Jul 17;
Bluett RJ, Gamble-George JC, Hermanson DJ, Hartley ND, Marnett LJ, Patel S, Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocanna… Translational psychiatry. 2014 4 e408
Neumann W, Crews BC, Sárosi MB, Daniel CM, Ghebreselasie K, Scholz MS, Marnett LJ, Hey-Hawkins E, Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance. ChemMedChem. 2014 Oct 15;
Manna JD, Wepy JA, Hsu K, Chang JW, Cravatt BF, Marnett LJ, Identification of the Major Prostaglandin Glycerol Ester Hydrolase in Human Cancer Cells. The Journal of biological chemistry. 2014 Oct 9;
Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ, Protein modification by adenine propenal. Chemical research in toxicology. 2014 Oct 20; 27 (10) 1732-42
Singh V, Fedeles BI, Li D, Delaney JC, Kozekov ID, Kozekova A, Marnett LJ, Rizzo CJ, Essigmann JM, Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ket… Chemical research in toxicology. 2014 Sep 15; 27 (9) 1619-31
Galligan JJ, Rose KL, Beavers WN, Hill S, Tallman KA, Tansey WP, Marnett LJ, Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigeneti… Journal of the American Chemical Society. 2014 Aug 27; 136 (34) 11864-6
Xu S, Rouzer CA, Marnett LJ, Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond. IUBMB life. 2014 Dec 23;
Shonesy BC, Bluett RJ, Ramikie TS, Báldi R, Hermanson DJ, Kingsley PJ, Marnett LJ, Winder DG, Colbran RJ, Patel S, Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signal… Cell reports. 2014 Dec 11; 9 (5) 1644-53
Uddin MJ, Elleman AV, Ghebreselasie K, Daniel CK, Crews BC, Nance KD, Huda T, Marnett LJ, Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors. ACS medicinal chemistry letters. 2014 Nov 13; 5 (11) 1254-8
Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ, Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Ne… The Journal of biological chemistry. 2014 Jan 14;
Codreanu SG, Ullery JC, Zhu J, Tallman KA, Beavers WN, Porter NA, Marnett LJ, Zhang B, Liebler DC, Alkylation damage by lipid electrophiles targets functional protein systems. Molecular & cellular proteomics : MCP. 2014 Jan 15;
Uddin MJ, Crews BC, Huda I, Ghebreselasie K, Daniel CK, Marnett LJ, Trifluoromethyl fluorocoxib a detects cyclooxygenase-2 expression in inflammatory tissues and human … ACS medicinal chemistry letters. 2014 Apr 10; 5 (4) 446-50
Rietjens IM, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Marnett LJ, Smith B, Adams T, Bastaki M, Harman C, Taylor S, The impact of structural and metabolic variation on the toxicity and carcinogenicity of hydroxy- and… Chemical research in toxicology. 2014 May 23;
Hermanson DJ, Gamble-George JC, Marnett LJ, Patel S, Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentatio… Trends in pharmacological sciences. 2014 May 17;
Perrone MG, Malerba P, Uddin MJ, Vitale P, Panella A, Crews BC, Daniel CK, Ghebreselasie K, Nickels M, Tantawy MN, Manning HC, Marnett LJ, Scilimati A, PET radiotracer [(18)F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preli… European journal of medicinal chemistry. 2014 Jun 10; 80 562-8
Neumann W, Crews BC, Marnett LJ, Hey-Hawkins E, Conjugates of Cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming Cisplati… ChemMedChem. 2014 Jun 9 (6) 1150-3
Marnett LJ, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Rietjens IM, Smith RL, Adams TB, Bastaki M, Harman CL, McGowen MM, Taylor SV, GRASr2 evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally re… Journal of food science. 2014 Apr 79 (4) R428-41

2013

Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ, Replication, Repair, and Translesion Polymerase Bypass of N(6)-Oxopropenyl-2 Prime-deoxyadenosine. Biochemistry. 2013 Dec 3; 52 (48) 8766-76
Shuck SC, Rose KL, Marnett LJ, Mass Spectrometric Methods for the Analysis of Nucleoside-Protein Cross-Links: Application to Oxopro… Chemical research in toxicology. 2013 Dec 20;
Windsor MA, Valk PL, Xu S, Banerjee S, Marnett LJ, Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumira… Bioorganic & medicinal chemistry letters. 2013 Nov 1; 23 (21) 5860-4
Liu Q, Ullery J, Zhu J, Liebler DC, Marnett LJ, Zhang B, RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome resp… Molecular bioSystems. 2013 Sep 20;
Hermanson DJ, Hartley ND, Gamble-George J, Brown N, Shonesy BC, Kingsley PJ, Colbran RJ, Reese J, Marnett LJ, Patel S, Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. Nature neuroscience. 2013 Sep 16 (9) 1291-8
Aldrovandi M, Hammond VJ, Podmore H, Hornshaw M, Clark SR, Marnett LJ, Slatter DA, Murphy RC, Collins PW, O'Donnell VB, Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibi… Journal of lipid research. 2013 Nov 54 (11) 3085-97
Soares CO, Boiani M, Marnett LJ, Bechara EJ, Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imb… Free radical research. 2013 Sep 47 (9) 672-82
Blobaum AL, Uddin MJ, Felts AS, Crews BC, Rouzer CA, Marnett LJ, The 2 Prime-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor. ACS medicinal chemistry letters. 2013 May 9; 4 (5) 486-490
Mohebati A, Milne GL, Zhou XK, Duffield-Lillico AJ, Boyle JO, Knutson A, Bosworth BP, Kingsley PJ, Marnett LJ, Brown PH, Akpa EG, Szabo E, Dannenberg AJ, Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers. Cancer prevention research (Philadelphia, Pa.). 2013 Jul 6 (7) 646-55
Cekanova M, Uddin MJ, Bartges JW, Callens A, Legendre AM, Rathore K, Wright L, Carter A, Marnett LJ, Molecular imaging of cyclooxygenase-2 in canine transitional cell carcinomas in vitro and in vivo. Cancer prevention research (Philadelphia, Pa.). 2013 May 6 (5) 466-76
Uddin MJ, Crews BC, Ghebreselasie K, Marnett LJ, Design, synthesis, and structure-activity relationship studies of fluorescent inhibitors of cycloxyg… Bioconjugate chemistry. 2013 Apr 17; 24 (4) 712-23
Connor RE, Codreanu SG, Marnett LJ, Liebler DC, Targeted protein capture for analysis of electrophile-protein adducts. Methods in molecular biology (Clifton, N.J.). 2013 987 163-76
Liedtke AJ, Adeniji AO, Chen M, Byrns MC, Jin Y, Christianson DW, Marnett LJ, Penning TM, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β… Journal of medicinal chemistry. 2013 Mar 28; 56 (6) 2429-46
Boiani M, Daniel C, Liu X, Hogarty MD, Marnett LJ, The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistanc… The Journal of biological chemistry. 2013 Mar 8; 288 (10) 6980-90
Tallman KA, Armstrong MD, Milne SB, Marnett LJ, Brown HA, Porter NA, Cobalt carbonyl complexes as probes for alkyne-tagged lipids. Journal of lipid research. 2013 Mar 54 (3) 859-68
Sevick-Muraca EM, Akers WJ, Joshi BP, Luker GD, Cutler CS, Marnett LJ, Contag CH, Wang TD, Azhdarinia A, Advancing the translation of optical imaging agents for clinical imaging. Biomedical optics express. 2013 Jan 1; 4 (1) 160-70
Laube M, Neumann W, Scholz M, Lönnecke P, Crews B, Marnett LJ, Pietzsch J, Kniess T, Hey-Hawkins E, 2-Carbaborane-3-phenyl-1H-indoles–synthesis via McMurry reaction and cyclooxygenase (COX) inhibitio… ChemMedChem. 2013 Feb 8 (2) 329-35
Aluise CD, Rose K, Boiani M, Reyzer ML, Manna JD, Tallman K, Porter NA, Marnett LJ, Peptidyl-prolyl cis/trans-isomerase A1 (Pin1) is a target for modification by lipid electrophiles. Chemical research in toxicology. 2013 Feb 18; 26 (2) 270-9
Yang Y, Yang H, Wang Z, Varadaraj K, Kumari SS, Mergler S, Okada Y, Saika S, Kingsley PJ, Marnett LJ, Reinach PS, Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory resp… Cellular signalling. 2013 Feb 25 (2) 501-11

2012

Musee J, Marnett LJ, Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to pero… The Journal of biological chemistry. 2012 Oct 26; 287 (44) 37383-94
Xu S, Mueser TC, Marnett LJ, Funk MO, Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-bindi… Structure (London, England : 1993). 2012 Sep 5; 20 (9) 1490-7
Scholz M, Blobaum AL, Marnett LJ, Hey-Hawkins E, Ortho-carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors. Bioorganic & medicinal chemistry. 2012 Aug 1; 20 (15) 4830-7
Eisenbrand G, Gates KS, Hecht SS, Janzowski C, Keefer LK, Marnett LJ, Tannenbaum SR, Richard Loeppky (1937-2012). Chemical research in toxicology. 2012 Jun 18; 25 (6) 1155-6
Aldrich MB, Marshall MV, Sevick-Muraca EM, Lanza G, Kotyk J, Culver J, Wang LV, Uddin J, Crews BC, Marnett LJ, Liao JC, Contag C, Crawford JM, Wang K, Reisdorph B, Appelman H, Turgeon DK, Meyer C, Wang T, Seeing it through: translational validation of new medical imaging modalities. Biomedical optics express. 2012 Apr 1; 3 (4) 764-76
Ullery JC, Marnett LJ, Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Inve… Biochimica et biophysica acta. 2012 Oct 1818 (10) 2424-35
Marnett LJ, Inflammation and cancer: chemical approaches to mechanisms, imaging, and treatment. The Journal of organic chemistry. 2012 Jun 15; 77 (12) 5224-38
Liedtke AJ, Crews BC, Daniel CM, Blobaum AL, Kingsley PJ, Ghebreselasie K, Marnett LJ, Cyclooxygenase-1-selective inhibitors based on the (E)-2 Prime-des-methyl-sulindac sulfide scaffold. Journal of medicinal chemistry. 2012 Mar 8; 55 (5) 2287-300
Marnett LJ, On a high note. Chemical research in toxicology. 2012 Jan 13; 25 (1) 1
Akingbade D, Kingsley PJ, Shuck SC, Cooper T, Carnahan R, Szekely J, Marnett LJ, Selection of monoclonal antibodies against 6-oxo-M(1)dG and their use in an LC-MS/MS assay for the p… Chemical research in toxicology. 2012 Feb 20; 25 (2) 454-61
Liedtke AJ, Kim K, Stec DF, Sulikowski GA, Marnett LJ, Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkano… Tetrahedron. 2012 Dec 2; 68 (48) 10049-10058
Cekanova M, Uddin MJ, Legendre AM, Galyon G, Bartges JW, Callens A, Martin-Jimenez T, Marnett LJ, Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygen… Journal of biomedical optics. 2012 Nov 17 (11) 116002
Windsor MA, Hermanson DJ, Kingsley PJ, Xu S, Crews BC, Ho W, Keenan CM, Banerjee S, Sharkey KA, Marnett LJ, Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Pro… ACS medicinal chemistry letters. 2012 Sep 13; 3 (9) 759-763