Aspects of Prostaglandin Glycerol Ester Biology

Authors

Kingsley PJ Philip J , Rouzer CA Carol A , Morgan AJ Amanda J , Patel S Sachin , Marnett LJ Lawrence J .
Advances in experimental medicine and biology. 2019 9 28; 1161().
77-88

Abstract

The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O into arachidonic acid (AA), resulting in an array of bioactive prostaglandins. However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG). The products of 2-AG oxygenation, prostaglandin glycerol esters (PG-Gs), are analogous to canonical prostaglandins. This chapter reviews the literature detailing the production, metabolism, and bioactivity of these compounds, as well as their detection in intact animals.