Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core
AUTHORS
Nance
KDKellie D ,
Days
ELEmily L ,
Weaver
CDC David ,
Coldren
AAnastasia ,
Farmer
TDTiffany D ,
Cho
HPHyekyung P ,
Niswender
CMColleen M ,
Blobaum
ALAnna L ,
Niswender
KDKevin D ,
Lindsley
CWCraig W .
Journal of medicinal chemistry. 2017 02 03; 60(4).
1611-1616
- PMID: 28103022[PubMed].