Lead optimization of the VU0486321 series of mGlu PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs
AUTHORS
Davis
DCDexter C ,
Bungard
JDJoseph D ,
Chang
SSichen ,
Rodriguez
ALAlice L ,
Blobaum
ALAnnie L ,
Boutaud
OOlivier ,
Melancon
BJBruce J ,
Niswender
CMColleen M ,
Jeffrey Conn
PP ,
Lindsley
CWCraig W .
Bioorganic & medicinal chemistry letters. 2020 11 27; 32().
127724
- PMID: 33253881[PubMed].
ABSTRACT
Tags: 2020