Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: potential role in liver fibrosis.
Authors
Amara| Lopez| Banan| Brown| Whalen| Myles| Ivy| Johnson| Schey| Tiriveedhi
S| K| B| SK| M| E| MT| T| KL| V
Suneetha| Karina| Babak| Sade-Kemi| Margaret| Elbert| Michael T| Terrance| Kevin L| Venkataswarup
.
Molecular immunology. 2015 3 ; 64(1).
26-35
Molecular immunology. 2015 3 ; 64(1).
26-35
Abstract
The pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-17, have been implicated in the pathogenesis of liver fibrosis. In this study, we investigated the role of TNFα and IL-17 toward induction of profibrotic factor, periostin.