Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis.
Authors
Amara
S
Suneetha
,
Lopez
K
Karina
,
Banan
B
Babak
,
Brown
SK
Sade-Kemi
,
Whalen
M
Margaret
,
Myles
E
Elbert
,
Ivy
MT
Michael T
,
Johnson
T
Terrance
,
Schey
KL
Kevin L
,
Tiriveedhi
V
Venkataswarup
.
Molecular immunology. 2015 3 ; 64(1).
26-35
Molecular immunology. 2015 3 ; 64(1).
26-35
Abstract
The pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-17, have been implicated in the pathogenesis of liver fibrosis. In this study, we investigated the role of TNFα and IL-17 toward induction of profibrotic factor, periostin.
The pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-17, have been implicated in the pathogenesis of liver fibrosis. In this study, we investigated the role of TNFα and IL-17 toward induction of profibrotic factor, periostin.