{"id":152,"date":"2020-06-15T22:40:21","date_gmt":"2020-06-15T22:40:21","guid":{"rendered":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/?page_id=152"},"modified":"2023-11-14T21:17:47","modified_gmt":"2023-11-14T21:17:47","slug":"updates","status":"publish","type":"page","link":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/research-projects\/covid-ventilator\/updates\/","title":{"rendered":"Updates"},"content":{"rendered":"\r\n<figure class=\"wp-block-video aligncenter\"><figcaption><div style=\"width: 750px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-152-1\" width=\"750\" height=\"314\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/24143536\/history.mp4?_=1\" \/><a href=\"https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/24143536\/history.mp4\">https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/24143536\/history.mp4<\/a><\/video><\/div>\r\n\r\n<b><b><b>\r\nThe History of COV<\/b><\/b><\/b>\r\n\r\n<hr \/>\r\n\r\n<div style=\"width: 750px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-152-2\" width=\"750\" height=\"422\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/24041454\/podcast.mp4?_=2\" \/><a href=\"https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/24041454\/podcast.mp4\">https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/24041454\/podcast.mp4<\/a><\/video><\/div>\r\n\r\n<strong>TAS Podcast<\/strong>\r\n\r\n<hr \/>\r\n\r\n<b><b>\u00a0<\/b><\/b>\r\n\r\n<\/figcaption><\/figure>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n<figure class=\"wp-block-embed-youtube aligncenter wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\r\n<div class=\"wp-block-embed__wrapper\">\r\n\r\n<iframe loading=\"lazy\" width=\"750\" height=\"422\" src=\"https:\/\/www.youtube.com\/embed\/fhXxsf_4Jzk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen title=\"Innovator&#39;s Mindset: Bob Webster - Vandy Vents\"><\/iframe>\r\n\r\n<\/div>\r\n<figcaption><b>Innovator&#8217;s Mindset Podcast<\/b><\/figcaption><\/figure>\r\n\r\n\r\n\r\n\r\n<hr class=\"wp-block-separator is-style-wide\" \/>\r\n\r\n\r\n\r\n\r\n<p class=\"has-text-align-left\"><strong>Testing performed with COV:<\/strong><\/p>\r\n\r\n\r\n\r\n<ul class=\"wp-block-list\">\r\n \t<li>Live Porcine Model (April 3, April 8)<\/li>\r\n \t<li>CPR Mannequin (March 29)<\/li>\r\n \t<li>Isolated Pig Lung (March 29)<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n\r\n<hr class=\"wp-block-separator is-style-wide\" \/>\r\n\r\n\r\n\r\n\r\n\r\nMay 11: A Github repository with the full firmware code is posted on the Downloads page.\r\n\r\n\r\n\r\n\r\n\r\nApril 24: A bunch of 4.0s are starting to come together at the Wond&#8217;ry! See the image below. We&#8217;ve also had a unit running for 11 days straight (since April 13th) with no observable signs of fatigue or wear.\r\n\r\n\r\n\r\n\r\n<div class=\"wp-block-image\">\r\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-213 size-full\" src=\"https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/23141220\/buncha_vents-1024x497.jpg\" alt=\"\" width=\"1024\" height=\"497\" srcset=\"https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/23141220\/buncha_vents-1024x497.jpg 1024w, https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/23141220\/buncha_vents-1024x497-300x146.jpg 300w, https:\/\/cdn-dev.vanderbilt.edu\/vu-web\/lab-wpcontent\/sites\/122\/2020\/06\/23141220\/buncha_vents-1024x497-768x373.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\r\n<\/div>\r\n\r\n\r\n\r\n\r\nApril 23: An Emergency Use Authorization (EUA) application based on the CoV 4.0 design was successfully submitted to the FDA.\r\n\r\n\r\n\r\n\r\n\r\nApril 22: Histology results from our 4-hour live swine study indicate no gross evidence of barotrauma or atelectasis. A fully-integrated 4.0 system (with on-board control) has been running for 96 hours straight (since April 18th) with no issues. Assembled units are transported from Ft. Houston to the Wond&#8217;ry for further control electronics integration and storage.\r\n\r\n\r\n\r\n\r\n\r\nApril 17-19: First fully-integrated CoV version 4.0 units, with on-board controls, improved safety features and a mechanical quick-release, are assembled at Make Nashville. Long-term testing commences to assess integrated system robustness. Mechanical assembly instructions for the latest unit are forthcoming.\r\n\r\n\r\n\r\n\r\n\r\nApril 13-15: 20 control electronics boxes are assembled, with enough components to build 80 more if needed. Long-term testing commences on a version 4.0 mechanical subsystem.\r\n\r\n\r\n\r\n\r\n\r\nApril 12: Comprehensive Wiring and Assembly instructions for the control box are posted on the Downloads page.\r\n\r\n\r\n\r\n\r\n\r\nApril 9-12: Fabrication commences on 100 units.\r\n\r\n\r\n\r\n\r\n\r\nApril 8: 4-hour live swine study was a success, with no complications or adverse events. Inspiratory pressure, end-tidal CO2 levels, and blood-gas levels were all clinically acceptable throughout. Currently awaiting histology results.\r\n\r\n\r\n\r\n\r\n\r\nApril 7: Breathing-assist tested, and second animal study scheduled for the morning of April 8th to test long-term ventilation.\r\n\r\n\r\n\r\n\r\n\r\nApril 5: Alarms and mechanical safety features integrated.\r\n\r\n\r\n\r\n\r\n\r\nApril 4: Breathing-assist functionality integrated.\r\n\r\n\r\n\r\n\r\n\r\nApril 3: First live animal study on a porcine model with CoV v3.1 was a success.\r\n\r\n\r\n\r\n\r\n\r\nApril 2: Nissan donates 100 wiper motors. Make Nashville joins the team as a fabrication facility.\r\n\r\n\r\n\r\n\r\n\r\nApril 1: IACUC protocol approved. First animal study scheduled.\r\n\r\n\r\n\r\n\r\n\r\nMarch 30-April 1: Substantial how-to content loaded onto VandyVents.com. Parts to be able to build 100 units arrive.\r\n\r\n\r\n\r\n\r\n\r\nMarch 30: IACUC Protocol submitted for first animal test. Second copy of V3 design fabricated. Long-term running tests initiated. Ongoing discussions regarding clinical considerations.\r\n\r\n\r\n\r\n\r\n\r\nMarch 29: Motor control and electronic pressure sensing integrated into V3 prototype. VandyVents web page goes live; thanks to Dominick Ropella for setting it up. George P. Johnson, Inc. volunteers to assist with fabricating plywood pieces. FDA approval efforts initiated.\r\n\r\n\r\n\r\n\r\n\r\nMarch 28: V3 prototype incorporating Nissan motors is completed.\r\n\r\n\r\n\r\n\r\n\r\nMarch 26: Nissan donates 5 initial windshield wiper motors from the Nissan Altima.\r\n\r\n\r\n\r\n\r\n\r\nMarch 25: First ex vivo test in a pig lung and with a respiratory training mannequin in CELA at Vanderbilt.\r\n\r\n\r\n\r\n\r\n\r\nMarch 24: Manometer-based sensor with light-based over and under-pressure sensors implemented. Arduino-based closed-loop control implemented.\r\n\r\n\r\n\r\n\r\n\r\nMarch 23: V2 prototype assembled. First Zoom team meeting with physicians Fabien Maldonado and Matthew Bacchetta. Arna Banerjee, Craig Rooks, Erin Gillaspie subsequently join the team.\r\n\r\n\r\n\r\n\r\n\r\nMarch 22: First prototype assembled. Postdoc Josh Gafford, and PhD students Max Emerson and Katy Riojas quickly volunteer to join the team.\r\n\r\n\r\n\r\n\r\n\r\nMarch 21: The VandyVents project begins. Duke Herrell calls Bob Webster and expresses urgent need to get working on a ventilator. Eric Barth tells Bob that Kevin Galloway has a great napkin-sketch ventilator design. Our team begins to come together.","protected":false},"excerpt":{"rendered":"<p>The History of COV TAS Podcast \u00a0 Innovator&#8217;s Mindset Podcast Testing performed with COV: Live Porcine Model (April 3, April 8) CPR Mannequin (March 29) Isolated Pig Lung (March 29) May 11: A Github repository with the full firmware code is posted on the Downloads page. April 24: A bunch of 4.0s are starting to&#8230;<\/p>\n","protected":false},"author":235,"featured_media":0,"parent":275,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-152","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/pages\/152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/users\/235"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/comments?post=152"}],"version-history":[{"count":5,"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/pages\/152\/revisions"}],"predecessor-version":[{"id":233,"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/pages\/152\/revisions\/233"}],"up":[{"embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/pages\/275"}],"wp:attachment":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/media?parent=152"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/medlab\/wp-json\/wp\/v2\/tags?post=152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}