Publications

2024

Islam M, Yang Y, Simmons AJ, Shah VM, Musale KP, Xu Y, Tasneem N, Chen Z, Trinh LT, Molina P, Ramirez-Solano MA, Sadien ID, Dou J, Rolong A, Chen K, Magnuson MA, Rathmell JC, Macara IG, Winton DJ, Liu Q, Zafar H, Kalhor R, Church GM, Shrubsole MJ, Coffey RJ, Lau KS, Temporal recording of mammalian development and precancer Nature. 2024 Oct 30; 634 (8036) 1187-1195

2022

Overway E M, Bosma K J, Claxton D P, Oeser J K, Singh K, Breidenbach L B, Mchaourab H S, Davis L K, O'Brien R M, Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose J Biol Chem. J Biol Chem. 2022 Feb 298 (2) 101534
Del Alamo D, Sala D, Mchaourab HS, Meiler J, Sampling alternative conformational states of transporters and receptors with AlphaFold2 Elife. 2022 Mar 3; 11 (Online ahead of print) e75751
Claxton DP, Overway EM, Oeser JK, O'Brien RM, Mchaourab HS, Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1 J Biol Chem. 2022 Jan 298 (1) 101520

2021

Thaker TM, Mishra S, Zhou W, Mohan M, Tang Q, Faraldo-Gomé J, Mchaourab HS, Tomasiak TM, Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter Nat Chem Biol. 2021 Dec 20; (Online ahead of print)
Schiemann O, Heubach CA, Abdullin D, Ackermann K, Azarkh M, Bagryanskaya EG, Drescher M, Endeward B, Freed JH, Galazzo L, Goldfarb D, Hett T, Hofer LE, Ibáñez LF, Hustedt EJ, Kucher S, Kuprov I, Lovett JE, Meyer A, Ruthstein S, Saxena S, Stoll S, Timmel CR, Valentin MD, Mchaourab HS, Prisner TF, Bode BE, Bordignon E, Bennati M, Jeschke G, Benchmark Test and Guidelines for DEER/PELDOR Experiments on Nitroxide-Labeled Biomolecules J Am Chem Soc. 2021 Nov 3; 143 (43) 17875-17890
Hustedt EJ, Stein RA, Mchaourab HS, Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations J Gen Physiol. 2021 Nov 1; 53 (11) e201711954
Del Alamo D, Jagessar KL, Meiler J, Mchaourab HS, Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER distance restraints PLoS Comput Biol. 2021 Jun 16; 7 (6) e1009107
Aguilar J, Cheng MH, Font J, Schwartz AC, Ledwitch K, Duran A, Mabry SJ, Belovich AN, Zhu Y, Carter AM, Shi L, Kurian MA, Fenollar-Ferrer C, Meiler J, Ryan RM, Mchaourab HS, Bahar, Matthies HJg, Galli A, Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia Elife. 2021 May 18; 10 (e68039)
Del Alamo D, Govaerts C, Mchaourab HS, AlphaFold2 predicts the inward-facing conformation of the multidrug transporter LmrP Proteins. 2021 May 11; 89 (9) 1226–1228
Claxton DP, Jagessar KL, Mchaourab HS, Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters J Mol Biol . 2021 Aug 6; 433 (16) 166959
Castellano S, Claxton DP, Ficici E, Kusakizako T, Stix R, Zhou W, Nureki O, Mchaourab HS, Faraldo-Gómez JD, Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na + in ion-coupled drug efflux J Biol Chem. 2021 Jan 5; 296 (100262)

2020

Han B, Porta JC, Hanks JL, Peskova Y, Binshtein E, Dryden K, Claxton DP, Mchaourab HS, Karakas E, Ohi MD, Kenworthy AK, Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy Sci Adv. 2020 Dec 2; 6 (49) eabc6185
Yardeni EH, Mishra S, Stein RA, Bibi E, Mchaourab HS, The Multidrug Transporter MdfA Deviates from the Canonical Model of Alternating Access of MFS Transporters J Mol Biol. 2020 Sep 18; 20 (432) 5665-5680
Debruycker V, Hutchin A, Masureel M, Masureel E, Martens C, Legrand P, Stein RA, Mchaourab HS, Faraldo-Gómez JD, Remaut H, Govaerts C, An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity Nat Struct Mol Biol. 2020 Sep 27; (9) 829-835
Chavan S, Cheng C, Jiang T, Mathews I, Stein RA, Koehl A, Mchaourab HS, Tajkhorshid E, Maduke M, A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl -/H + transport cycle Elife. 2020 Apr 20; (9) e53479
Yang Z, Stein RA, Ngendahimana T, Pink M, Rajca S, Jeschke G, Eaton S, Mchaourab HS, Rajca A, Supramolecular Approach to Electron Paramagnetic Resonance Distance Measurement of Spin-Labeled Proteins J Phys Chem B. 2020 Apr 23; 16 (124) 3291–3299
Jagessar L, Claxton P, Stein RA, Mchaourab HS, Sequence and structural determinants of ligand-dependent alternating access of a MATE transporter Proceedings of the National Academy of Sciences. 2020 Feb 19;
Del Alamo D, Tessemer H, Stein RA, Felix B, Mchaourab HS, Meiler J, Rapid Simulation of Unprocessed DEER Decay Data for Protein Fold Prediction Biophysical Journal. 2020 Jan 21; 2 (118) 366-375

2019

Yardeni E, Bahrenberg T, Stein RA, Mishra S, Zomot E, Graham B, Tuck K, Huber T, Bibi E, Mchaourab HS, Goldfarb D, Probing the solution structure of the E. coli multidrug transporter MdfA using DEER distance measurements with nitroxide and Gd(III) spin labels Scientific Reports . 2019 Aug 29; 9 (1) 12528
Dastvan R, Mishra S, Peskova YB, Robert N, Mchaourab HS, Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors Science. 2019 May 17; 364 (6441) 689-692
Campbell NG, Shekar A, Aguilar JI, Peng D, Navratna V, Yang D, Morley AN, Duran AM, Galli G, O'Grady B, Ramachandran R, Sutcliffe JS, Sitte HH, Erreger K, Meiler J, Stockner T, Bellan LM, Matthies HJG, Gouaux E, Mchaourab HS, Galli A, Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in Proceedings of the National Academy of Sciences of the United States of America. 2019 Feb 12; 116 (9) 3853-3862

2018

Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J, Conformational transitions of the sodium-dependent sugar transporter, vSGLT Proceedings of the National Academy of Sciences of the United States of America. 2018 Mar 05; 115 (12) E2742-E2751
Song X, Jensen MØ, Jogini V, Stein RA, Lee CH, Mchaourab HS, Shaw DE, Gouaux E, Mechanism of NMDA receptor channel block by MK-801 and memantine Nature. 2018 Apr 18; 556 (7702) 515-519
Claxton DP, Jagessar KL, Steed PR, Stein RA, Mchaourab HS, Sodium and proton coupling in the conformational cycle of a MATE antiporter from Proceedings of the National Academy of Sciences of the United States of America. 2018 Jun 18; 115 (27) E6182-E6190
Mishra S, Chandler SA, Williams D, Claxton DP, Koteiche HA, Stewart PL, Benesch JLP, Mchaourab HS, Engineering of a Polydisperse Small Heat-Shock Protein Reveals Conserved Motifs of Oligomer Plasticity Structure (London, England : 1993). 2018 Jul 05; 26 (8) 1116-1126.e4
Warren GM, Stein RA, Mchaourab HS, Eichman BF, Movement of the RecG Motor Domain upon DNA Binding Is Required for Efficient Fork Reversal International journal of molecular sciences. 2018 Oct 06; 19 (10)
Kusakizako T, Claxton DP, Tanaka Y, Maturana AD, Kuroda T, Ishitani R, Mchaourab HS, Nureki O, Structural Basis of H-Dependent Conformational Change in a Bacterial MATE Transporter Structure (London, England : 1993). 2018 Nov 15; 27 (2) 293-301.e3
Wu SY, Zou P, Mishra S, Mchaourab HS, Transgenic zebrafish models reveal distinct molecular mechanisms for cataract-linked αA-crystallin mutants PloS one. 2018 Nov 26; 13 (11) e0207540

2017

Verhalen B, Dastvan R, Thangapandian S, Peskova Y, Koteiche HA, Nakamoto RK, Tajkhorshid E, Mchaourab HS, Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein Nature. 2017 Mar 13; 543 (7647) 738-741
Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJJM, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, Goloubinoff P, Gusev N, Haslbeck M, Hightower LE, Kampinga HH, Klevit RE, Liberek K, Mchaourab HS, McMenimen KA, Poletti A, Quinlan R, Strelkov SV, Toth ME, Vierling E, Tanguay RM, The growing world of small heat shock proteins: from structure to functions Cell stress & chaperones. 2017 Mar 31; 22 (4) 601-611
Collauto A, Mishra S, Litvinov A, Mchaourab HS, Goldfarb D, Direct Spectroscopic Detection of ATP Turnover Reveals Mechanistic Divergence of ABC Exporters Structure (London, England : 1993). 2017 Jul 14; 25 (8) 1264-1274.e3
Mishra S, Wu SY, Fuller AW, Wang Z, Rose KL, Schey KL, Mchaourab HS, Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart The Journal of biological chemistry. 2017 Nov 21; 293 (2) 740-753

2016

Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E, Mechanism of NMDA Receptor Inhibition and Activation. Cell. 2016 Apr 6;
Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL, Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation. Cell. 2016 Feb 25; 164 (5) 922-36
Khantwal CM, Abraham SJ, Han W, Jiang T, Chavan TS, Cheng RC, Elvington SM, Liu CW, Mathews II, Stein RA, Mchaourab HS, Tajkhorshid E, Maduke M, Revealing an outward-facing open conformational state in a CLC Cl(-)/H(+) exchange transporter. eLife. 2016 5
Dastvan R, Fischer AW, Mishra S, Meiler J, Mchaourab HS, Protonation-dependent conformational dynamics of the multidrug transporter EmrE. Proceedings of the National Academy of Sciences of the United States of America. 2016 Feb 2; 113 (5) 1220-5
Krug U, Alexander NS, Stein RA, Keim A, Mchaourab HS, Sträter N, Meiler J, Characterization of the Domain Orientations of E. coli 5′-Nucleotidase by Fitting an Ensemble of Co… Structure (London, England : 1993). 2016 Jan 5; 24 (1) 43-56
Martens C, Stein RA, Masureel M, Roth A, Mishra S, Dawaliby R, Konijnenberg A, Sobott F, Govaerts C, Mchaourab HS, Lipids modulate the conformational dynamics of a secondary multidrug transporter Nature structural & molecular biology. 2016 Jul 11; 23 (8) 744-51
Wu SY, Zou P, Fuller AW, Mishra S, Wang Z, Schey KL, Mchaourab HS, Expression of Cataract-linked γ-Crystallin Variants in Zebrafish Reveals a Proteostasis Network That Senses Protein Stability The Journal of biological chemistry. 2016 Oct 21; 291 (49) 25387-25397
Kazmier K, Claxton DP, Mchaourab HS, Alternating access mechanisms of LeuT-fold transporters: trailblazing towards the promised energy landscapes Current opinion in structural biology. 2016 Dec 30; 45 100-108

2015

Koteiche HA, Claxton DP, Mishra S, Stein RA, McDonald ET, Mchaourab HS, Species-Specific Structural and Functional Divergence of α-Crystallins: Zebrafish αBa- and Rodent … Biochemistry. 2015 Sep 29; 54 (38) 5949-58
Zou P, Wu SY, Koteiche HA, Mishra S, Levic DS, Knapik E, Chen W, Mchaourab HS, A conserved role of αA-crystallin in the development of the zebrafish embryonic lens. Experimental eye research. 2015 Sep 138 104-13
Claxton DP, Kazmier K, Mishra S, Mchaourab HS, Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR S… Methods in enzymology. 2015 564 349-87
Mori T, Mchaourab H, Johnson CH, Circadian Clocks: Unexpected Biochemical Cogs. Current biology : CB. 2015 Oct 5; 25 (19) R842-4
Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S, A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation. The Journal of general physiology. 2015 Oct 146 (4) 323-40
Kaur H, Lakatos A, Spadaccini R, Vogel R, Hoffmann C, Becker-Baldus J, Ouari O, Tordo P, Mchaourab H, Glaubitz C, The ABC exporter MsbA probed by solid state NMR – challenges and opportunities. Biological chemistry. 2015 Sep 396 (9-10) 1135-49
Meyer V, Swanson MA, Clouston LJ, Boratyński PJ, Stein RA, Mchaourab HS, Rajca A, Eaton SS, Eaton GR, Room-temperature distance measurements of immobilized spin-labeled protein by DEER/PELDOR. Biophysical journal. 2015 Mar 10; 108 (5) 1213-9
Anderson DM, Floyd KA, Barnes S, Clark JM, Clark JI, Mchaourab H, Schey KL, A method to prevent protein delocalization in imaging mass spectrometry of non-adherent tissues: app… Analytical and bioanalytical chemistry. 2015 Mar 407 (8) 2311-20

2014

Kazmier K, Sharma S, Islam SM, Roux B, Mchaourab HS, Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1. Proceedings of the National Academy of Sciences of the United States of America. 2014 Oct 14; 111 (41) 14752-7
Yu Z, Quine RW, Rinard GA, Tseitlin M, Elajaili H, Kathirvelu V, Clouston LJ, Boratyński PJ, Rajca A, Stein R, Mchaourab H, Eaton SS, Eaton GR, Rapid-scan EPR of immobilized nitroxides. Journal of magnetic resonance (San Diego, Calif. : 1997). 2014 Oct 247 67-71
Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E, Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states. Cell. 2014 Aug 14; 158 (4) 778-92
Mishra S, Verhalen B, Stein RA, Wen PC, Tajkhorshid E, Mchaourab HS, Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric AB… eLife. 2014 3 e02740
Kazmier K, Sharma S, Quick M, Islam SM, Roux B, Weinstein H, Javitch JA, McHaourab HS, Conformational dynamics of ligand-dependent alternating access in LeuT. Nature structural & molecular biology. 2014 May 21 (5) 472-9
Masureel M, Martens C, Stein RA, Mishra S, Ruysschaert JM, Mchaourab HS, Govaerts C, Protonation drives the conformational switch in the multidrug transporter LmrP. Nature chemical biology. 2014 Feb 10 (2) 149-55

2013

Hamilton PJ, Campbell NG, Sharma S, Erreger K, Herborg Hansen F, Saunders C, Belovich AN, , Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A, De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectr… Molecular psychiatry. 2013 Dec 18 (12) 1315-23
Steed PR, Stein RA, Mishra S, Goodman MC, McHaourab HS, Na⁺-substrate coupling in the multidrug antiporter norm probed with a spin-labeled substrate. Biochemistry. 2013 Aug 27; 52 (34) 5790-9
Wen PC, Verhalen B, Wilkens S, Mchaourab HS, Tajkhorshid E, On the origin of large flexibility of P-glycoprotein in the inward-facing state. The Journal of biological chemistry. 2013 Jun 28; 288 (26) 19211-20
Islam SM, Stein RA, McHaourab HS, Roux B, Structural refinement from restrained-ensemble simulations based on EPR/DEER data: application to T4… The journal of physical chemistry. B. 2013 May 2; 117 (17) 4740-54
Shi J, Koteiche HA, McDonald ET, Fox TL, Stewart PL, McHaourab HS, Cryoelectron microscopy analysis of small heat shock protein 16.5 (Hsp16.5) complexes with T4 lysozy… The Journal of biological chemistry. 2013 Feb 15; 288 (7) 4819-30
Hamilton PJ, Campbell NG, Sharma S, Erreger K, Hansen FH, Saunders C, Belovich AN, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A, Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associat… Molecular psychiatry. 2013 Dec 18 (12) 1235
Steed PR, Zou P, Trone KE, Mchaourab HS, Structure and pH-induced structural rearrangements of the putative multidrug efflux pump EmrD in lip… Biochemistry. 2013 Nov 12; 52 (45) 7964-74
Alexander NS, Stein RA, Koteiche HA, Kaufmann KW, McHaourab HS, Meiler J, RosettaEPR: rotamer library for spin label structure and dynamics. PloS one. 2013 8 (9) e72851

2012

Mishra S, Stein RA, McHaourab HS, Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins. FEBS letters. 2012 Feb 17; 586 (4) 330-6
Mishra S, Stein RA, Mchaourab HS, Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins FEBS Letters. 2012 Jan 29; 4 (586) 330-6
Yirdaw RB, McHaourab HS, Direct observation of T4 lysozyme hinge-bending motion by fluorescence correlation spectroscopy. Biophysical journal. 2012 Oct 3; 103 (7) 1525-36
McHaourab HS, Lin YL, Spiller BW, Crystal structure of an activated variant of small heat shock protein Hsp16.5. Biochemistry. 2012 Jun 26; 51 (25) 5105-12
McDonald ET, Bortolus M, Koteiche HA, Mchaourab HS, Sequence, structure, and dynamic determinants of Hsp27 (HspB1) equilibrium dissociation are encoded … Biochemistry. 2012 Feb 14; 51 (6) 1257-68

2011

Hoffman L, Stein RA, Colbran RJ, Mchaourab HS, Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation. The EMBO journal. 2011 Apr 6; 30 (7) 1251-62
Kazmier K, Alexander NS, Meiler J, McHaourab HS, Algorithm for selection of optimized EPR distance restraints for de novo protein structure determina… Journal of structural biology. 2011 Mar 173 (3) 549-57
Hirst SJ, Alexander N, McHaourab HS, Meiler J, RosettaEPR: an integrated tool for protein structure determination from sparse EPR data. Journal of structural biology. 2011 Mar 173 (3) 506-14
McHaourab HS, Steed PR, Kazmier K, Toward the fourth dimension of membrane protein structure: insight into dynamics from spin-labeling … Structure (London, England : 1993). 2011 Nov 9; 19 (11) 1549-61
Mushrush DJ, Koteiche HA, Sammons MA, Link AJ, McHaourab HS, Lacy DB, Studies of the mechanistic details of the pH-dependent association of botulinum neurotoxin with memb… The Journal of biological chemistry. 2011 Jul 29; 286 (30) 27011-8

2010

Tycko R, Savtchenko R, Ostapchenko VG, Makarava N, Baskakov IV, The α-helical C-terminal domain of full-length recombinant PrP converts to an in-register parallel … Biochemistry. 2010 Nov 9; 49 (44) 9488-97
Qin X, Byrne M, Mori T, Zou P, Williams DR, McHaourab H, Johnson CH, Intermolecular associations determine the dynamics of the circadian KaiABC oscillator. Proceedings of the National Academy of Sciences of the United States of America. 2010 Aug 17; 107 (33) 14805-10
Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS, Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium sy… Nature structural & molecular biology. 2010 Jul 17 (7) 822-9
Amadi ST, Koteiche HA, Mishra S, McHaourab HS, Structure, dynamics, and substrate-induced conformational changes of the multidrug transporter EmrE … The Journal of biological chemistry. 2010 Aug 20; 285 (34) 26710-8
Gustot A, Smriti, Ruysschaert JM, McHaourab H, Govaerts C, Lipid composition regulates the orientation of transmembrane helices in HorA, an ABC multidrug trans… The Journal of biological chemistry. 2010 May 7; 285 (19) 14144-51

2009

Zou P, Bortolus M, McHaourab HS, Conformational cycle of the ABC transporter MsbA in liposomes: detailed analysis using double electr… Journal of molecular biology. 2009 Oct 30; 393 (3) 586-97
McHaourab HS, Godar JA, Stewart PL, Structure and mechanism of protein stability sensors: chaperone activity of small heat shock protein… Biochemistry. 2009 May 12; 48 (18) 3828-37
Smriti P, Zou HS, McHaourab, Mapping daunorubicin-binding Sites in the ATP-binding cassette transporter MsbA using site-specific … The Journal of biological chemistry. 2009 May 15; 284 (20) 13904-13
Latham JC, Stein RA, Bornhop DJ, Mchaourab HS, Free-solution label-free detection of alpha-crystallin chaperone interactions by back-scattering int… Analytical chemistry. 2009 Mar 1; 81 (5) 1865-71
Kumar MS, Koteiche HA, Claxton DP, Mchaourab HS, Disulfide cross-links in the interaction of a cataract-linked alphaA-crystallin mutant with betaB1-c… FEBS letters. 2009 Jan 5; 583 (1) 175-9
Zou P, McHaourab HS, Alternating access of the putative substrate-binding chamber in the ABC transporter MsbA. Journal of molecular biology. 2009 Oct 30; 393 (3) 574-85

2008

McHaourab HS, Mishra S, Koteiche HA, Amadi SH, Role of sequence bias in the topology of the multidrug transporter EmrE. Biochemistry. 2008 Aug 5; 47 (31) 7980-2
Alexander N, Bortolus M, Al-Mestarihi A, Mchaourab H, Meiler J, De novo high-resolution protein structure determination from sparse spin-labeling EPR data. Structure (London, England : 1993). 2008 Feb 16 (2) 181-95
Claxton DP, Zou P, Mchaourab HS, Structure and orientation of T4 lysozyme bound to the small heat shock protein alpha-crystallin. Journal of molecular biology. 2008 Jan 25; 375 (4) 1026-39

2007

McHaourab HS, Kumar MS, Koteiche HA, Specificity of alphaA-crystallin binding to destabilized mutants of betaB1-crystallin. FEBS letters. 2007 May 15; 581 (10) 1939-43
Koteiche HA, Kumar MS, McHaourab HS, Analysis of betaB1-crystallin unfolding equilibrium by spin and fluorescence labeling: evidence of a… FEBS letters. 2007 May 15; 581 (10) 1933-8
Mori T, Williams DR, Byrne MO, Qin X, Egli M, Mchaourab HS, Stewart PL, Johnson CH, Elucidating the ticking of an in vitro circadian clockwork. PLoS biology. 2007 Apr 5 (4) e93
Zou P, Surendhran K, Mchaourab HS, Distance measurements by fluorescence energy homotransfer: evaluation in T4 lysozyme and correlation… Biophysical journal. 2007 Feb 15; 92 (4) L27-9
Cobb NJ, Sönnichsen FD, McHaourab H, Surewicz WK, Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure. Proceedings of the National Academy of Sciences of the United States of America. 2007 Nov 27; 104 (48) 18946-51
Borbat PP, Surendhran K, Bortolus M, Zou P, Freed JH, Mchaourab HS, Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis. PLoS biology. 2007 Oct 5 (10) e271

2006

Shi J, Koteiche HA, McHaourab HS, Stewart PL, Cryoelectron microscopy and EPR analysis of engineered symmetric and polydisperse Hsp16.5 assemblies… The Journal of biological chemistry. 2006 Dec 29; 281 (52) 40420-8
Koteiche HA, Mchaourab HS, Mechanism of a hereditary cataract phenotype. Mutations in alphaA-crystallin activate substrate bind… The Journal of biological chemistry. 2006 May 19; 281 (20) 14273-9

2005

Koteiche HA, Chiu S, Majdoch RL, Stewart PL, Mchaourab HS, Atomic models by cryo-EM and site-directed spin labeling: application to the N-terminal region of Hs… Structure (London, England : 1993). 2005 Aug 13 (8) 1165-71
Altenbach C, Froncisz W, Hemker R, McHaourab H, Hubbell WL, Accessibility of nitroxide side chains: absolute Heisenberg exchange rates from power saturation EPR… Biophysical journal. 2005 Sep 89 (3) 2103-12
Dong J, Yang G, McHaourab HS, Structural basis of energy transduction in the transport cycle of MsbA. Science (New York, N.Y.). 2005 May 13; 308 (5724) 1023-8
Shashidharamurthy R, Koteiche HA, Dong J, McHaourab HS, Mechanism of chaperone function in small heat shock proteins: dissociation of the HSP27 oligomer is … The Journal of biological chemistry. 2005 Feb 18; 280 (7) 5281-9

2004

Sathish HA, Koteiche HA, McHaourab HS, Binding of destabilized betaB2-crystallin mutants to alpha-crystallin: the role of a folding interme… The Journal of biological chemistry. 2004 Apr 16; 279 (16) 16425-32

2003

Sathish HA, Stein RA, Yang G, Mchaourab HS, Mechanism of chaperone function in small heat-shock proteins. Fluorescence studies of the conformati… The Journal of biological chemistry. 2003 Nov 7; 278 (45) 44214-21
Koteiche HA, Reeves MD, McHaourab HS, Structure of the substrate binding pocket of the multidrug transporter EmrE: site-directed spin labe… Biochemistry. 2003 May 27; 42 (20) 6099-105
Koteiche HA, McHaourab HS, Mechanism of chaperone function in small heat-shock proteins. Phosphorylation-induced activation of … The Journal of biological chemistry. 2003 Mar 21; 278 (12) 10361-7

2002

Mchaourab HS, Dodson EK, Koteiche HA, Mechanism of chaperone function in small heat shock proteins. Two-mode binding of the excited states… The Journal of biological chemistry. 2002 Oct 25; 277 (43) 40557-66
Koteiche HA, Mchaourab HS, The determinants of the oligomeric structure in Hsp16.5 are encoded in the alpha-crystallin domain. FEBS letters. 2002 May 22; 519 (1-3) 16-22
Borbat PP, McHaourab HS, Freed JH, Protein structure determination using long-distance constraints from double-quantum coherence ESR: s… Journal of the American Chemical Society. 2002 May 15; 124 (19) 5304-14
Mansoor SE, McHaourab HS, Farrens DL, Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing th… Biochemistry. 2002 Feb 26; 41 (8) 2475-84

2000

Bova MP, McHaourab HS, Han Y, Fung BK, Subunit exchange of small heat shock proteins. Analysis of oligomer formation of alphaA-crystallin a… The Journal of biological chemistry. 2000 Jan 14; 275 (2) 1035-42
Kaplan RS, Mayor JA, Kotaria R, Walters DE, McHaourab HS, The yeast mitochondrial citrate transport protein: determination of secondary structure and solvent … Biochemistry. 2000 Aug 8; 39 (31) 9157-63
Haley DA, Bova MP, Huang QL, Mchaourab HS, Stewart PL, Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies. Journal of molecular biology. 2000 Apr 28; 298 (2) 261-72

1999

Koteiche HA, Mchaourab HS, Folding pattern of the alpha-crystallin domain in alphaA-crystallin determined by site-directed spin… Journal of molecular biology. 1999 Nov 26; 294 (2) 561-77
Mansoor SE, McHaourab HS, Farrens DL, Determination of protein secondary structure and solvent accessibility using site-directed fluoresce… Biochemistry. 1999 Dec 7; 38 (49) 16383-93
Barnes JP, Liang Z, Mchaourab HS, Freed JH, Hubbell WL, A multifrequency electron spin resonance study of T4 lysozyme dynamics. Biophysical journal. 1999 Jun 76 (6) 3298-306
Mchaourab HS, Kálai T, Hideg K, Hubbell WL, Motion of spin-labeled side chains in T4 lysozyme: effect of side chain structure. Biochemistry. 1999 Mar 9; 38 (10) 2947-55
Berengian AR, Parfenova M, Mchaourab HS, Site-directed spin labeling study of subunit interactions in the alpha-crystallin domain of small he… The Journal of biological chemistry. 1999 Mar 5; 274 (10) 6305-14

1998

Koteiche HA, Berengian AR, Mchaourab HS, Identification of protein folding patterns using site-directed spin labeling. Structural characteriz… Biochemistry. 1998 Sep 15; 37 (37) 12681-8

1997

Mchaourab HS, Oh KJ, Fang CJ, Hubbell WL, Conformation of T4 lysozyme in solution. Hinge-bending motion and the substrate-induced conformation… Biochemistry. 1997 Jan 14; 36 (2) 307-16
Mchaourab HS, Berengian AR, Koteiche HA, Site-directed spin-labeling study of the structure and subunit interactions along a conserved sequen… Biochemistry. 1997 Dec 2; 36 (48) 14627-34
Berengian AR, Bova MP, Mchaourab HS, Structure and function of the conserved domain in alphaA-crystallin. Site-directed spin labeling ide… Biochemistry. 1997 Aug 19; 36 (33) 9951-7
Qu K, Vaughn JL, Sienkiewicz A, Scholes CP, Fetrow JS, Kinetics and motional dynamics of spin-labeled yeast iso-1-cytochrome c: 1. Stopped-flow electron pa… Biochemistry. 1997 Mar 11; 36 (10) 2884-97

1996

Hubbell WL, Mchaourab HS, Altenbach C, Lietzow MA, Watching proteins move using site-directed spin labeling. Structure (London, England : 1993). 1996 Jul 15; 4 (7) 779-83
Mchaourab HS, Lietzow MA, Hideg K, Hubbell WL, Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics. Biochemistry. 1996 Jun 18; 35 (24) 7692-704

1995

Singh RJ, Feix JB, Mchaourab HS, Hogg N, Kalyanaraman B, Spin-labeling study of the oxidative damage to low-density lipoprotein. Archives of biochemistry and biophysics. 1995 Jun 20; 320 (1) 155-61

1994

Singh RJ, Hogg N, Mchaourab HS, Kalyanaraman B, Physical and chemical interactions between nitric oxide and nitroxides. Biochimica et biophysica acta. 1994 Dec 15; 1201 (3) 437-41
Mchaourab HS, Hyde JS, Feix JB, Binding and state of aggregation of spin-labeled cecropin AD in phospholipid bilayers: effects of su… Biochemistry. 1994 May 31; 33 (21) 6691-9

1993

Mchaourab HS, Hyde JS, Feix JB, Aggregation state of spin-labeled cecropin AD in solution. Biochemistry. 1993 Nov 9; 32 (44) 11895-902
Mchaourab HS, Pfenninger S, Antholine WE, Felix CC, Hyde JS, Kroneck PM, Multiquantum EPR of the mixed valence copper site in nitrous oxide reductase. Biophysical journal. 1993 May 64 (5) 1576-9