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Publications

2024

An Z, Fan QW, Wang L, Yoda H, Barata M, Jimenez-Morales D, Phillips J, Swaney D, Stevenson E, Lee E, Krogan N, Weiss W, EGFR and EGFRvIII coopt host defense pathways, promoting progression in glioblastoma Neuro-Oncology. 2024 Sep 9;
Yang J, Lewis S, Zi J, Andl T, Lee E, Andl D, Liu Q, Beauchamp D, Means L, Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma Journal of Pathology. 2024 Jun 26;
Diaz D, Bergdorf K, Loberg A, Phifer J, Xu J, Sheng Q, Chen S-C, Bryant M, Tigue L, Hartmann H, Rohde L, Netterville L, Baregamian, Goettel A, Ye F, Lee E, Weiss L, Wnt/β-catenin signaling is a therapeutic target in anaplastic thyroid carcinoma Endocrine. 2024 May 28;

2023

Spencer* Z, Ng* V, Benchabane H, Siddiqui G, Duwadi D, Maines B, Bryant J, Schwarzkopf A, Yuan K, Kassel S, Mishra A, Pimentel A, Lebensohn A, Rohatgi R, Gerber S, Robbins D, Lee** E, Ahmed** Y, The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6 Nature Communications. 2023 Oct 5; 14 (6174)
Ng* V, Spencer* Z, Neitzel L, Nayak A, Loberg M, Shen C, Kassel S, Kroh H, Ah Z, Anthony C, Bryant J, Lawson A, Goldsmith L, Benchabane H, Hensen A, Li J, D'Souza S, Lebensohn A, Rohatgi R, Weiss W, Weiss V, Williams C, Hong C, Robbins D, Ahmed** Y, Lee** E, The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling Nature Communications. 2023 Oct 5; 14 (6173)
Xu G, Loberg M, Gallant J-N, Sheng Q, Chen S-C, Lehmann B, Shaddy S, Tigue M, Phifer C, Wang L, Saab-Chalhoub M, Dehan L, Wei Q, Chen R, Li B, Kim C, Ferguson D, Netterville J, Rohde S, Solorzano C, Bischoff L, Baregamian N, Shaver A, Mehrad M, Ely K, Byrne D, Stricker T, Murphy B, Choe J, Kagohara L, Jaffee E, Huang E, Ye F, Lee E, Weiss V, Molecular signature incorporating the immune microenvironment enhances thyroid cancer outcome prediction Cell Genomics. 2023 Oct 11; (3)
Pilat J, Brown R, Chen Z, Berle N, Othon A, Washington M, Anand S, Kurokawa S, Ng V, Thompson J, Jacobse J, Goettel J, Lee E, Choksi Y, Lau K, Short S, Williams C, SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions Journal of Clinical Investigation. 2023 May 11;
Kassel* S, Hanson* J, Benchabane H, Saito-Diaz K, Cabel R, Goldsmith L, Taha M, Kanuganti A, Ng H, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss L, Robbins J, Thorne A, Ahmed** Y, Lee** E, USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling Science Signaling . 2023 Feb 7; 16 (771)
Cantoria MJ, Alizadeh E, Varghese R, Bunnag N, Pond K, Kettenbach A, Ahmed Y, Tyson J, Doubrovinski* K, Lee* E, Thorne* C, Feedback in the β-catenin destruction complex imparts bistability and cellular memory Proceedings of the National Academy of Sciences, USA. 2023 Jan 4; 120 (2)

2022

Tigue M, Loberg M, Goettel J, Weiss W, Lee E, Weiss V, Wnt signaling in the phenotype and function of tumor-associated macrophages Cancer Research. 2022 Oct 10;
Shen C, Nayak A, Neitzel R, Yang F, Li B, Williams H, Hong C, Ahmed Y, Lee E, Robbins J, The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon Journal of Biological Chemistry. 2022
Bergdorf K, Bauer A, Westover D, Phifer C, Tyson R, Lee E, Weiss L, Utilizing Three-Dimensional Culture Methods to Improve High-Throughput Drug Screening in Anaplastic Thyroid Carcinoma Cancers. 2022

2021

Borza M, Bolas G, Bock Fabian, Zhang X, Akabogu C, Zhang M-Z, de Caestecker M, Yang M, Yang H-C, Lee E, Gewin L, Fogo B, McDonald W-H, Zent R, Pozzi A, DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3 JCI Insight. 2021 Dec 23;
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ, The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Nature Communications. 2021 1 (12)
Phifer CJ, Bergdorf KN, Bechard ME, Vilgelm A, Baregamian N, McDonald OG, Lee E, Weiss V, Obtaining patient-derived cancer organoid cultures via fine-needle aspiration STAR Protocols. 2021 2 (1)

2020

Bergdorf K, Bharti V, Bauer J, Vilgelm A, Lee E, Weiss V, High-throughput drug screening of fine-needle aspiration-derived cancer organoids STAR Protocols. 2020 1 (3)
Shen C, Nayak A, Melendez RA, Wynn DT, Johnson J, Lee E, Ahmed Y, Robbins DJ, Casein Kinase 1α as a Regulator of Wnt-Driven Cancer International Journal of Molecular Sciences . 2020 Aug 18; 21 (16)
Vilgelm AE, Bergdorf K, Wolf M, Bharti V, Shattuck-Brandt R, Blevins A, Jones C, Phifer C, Lee MA, Lowe C, Rachel H, Boyd K, James N, Rohde S, Idrees K, Bauer JA, Westover D, Reinfeld B, Baregamian N, Richmond A, Rathmell K, Lee E, McDonald OG, Weiss VL, Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids iScience. 2020 Aug 21; 8 (23)
Anthony C, Robbins J, Ahmed Yashi, Lee Ethan, Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation Genes. 2020 Aug 4; 8 (11)
Nlandu-Khodo S, Osaki Y, Scarfe L, Yang H, Phillips-Mignemi M, Tonello J, Saito-Diaz K, Neelisetty S, Ivanova A, Huffstater T, McMahon R, Taketo MM, deCaestecker M, Kasinath B, Harris RC, Lee E, Gewin LS, Tubular β-catenin and FoxO3 interactions protect in chronic kidney disease. JCI Insight. 2020 May 21; 10 (5)
Sucre JMS, Vickers KC, Benjamin JT, Plosa EJ, Jetter CS, Cutrone A, Ransom M, Anderson Z, Sheng Q, Fensterheim BA, Ambalavanan N, Millis B, Lee E, Zijlstra A, Königshoff M, Blackwell TS, Guttentag SH, Hyperoxia Injury in the Developing Lung is Mediated by Mesenchymal Expression of Wnt5A. American Journal of Respiratory and Critical Care Medicine. 2020
Lee MA, Bergdorf KN, Phifer CJ, Jones CY, Byon SY, Sawyer LM, Weiss VL, Novel three-dimensional cultures provide insights into thyroid cancer behavior. Endocrine Related Cancer. 2020 27 (2) 111-121

2019

Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ, The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/km) of CK1α. Biochemistry. 2019 58 (51) 5102-6
Cabel CR, Alizadeh E, Robbins DJ, Ahmed* Y, Lee* E, Thorne* CA, Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt signaling in APC-Deficient Cells. Developmental Cell. 2019 49 827-8
Xie S, Fu W, Hu X, Lai KS, Peng X, Zhou Y, Zhu X, Christov P, Sawyer L, Ni TT, Sulikowski GA, Yang Z, Lee E, Zeng C, Wang WE, Zhong TP, Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair. Journal of Molecular Cell Biology. 2019 12 (1) 42-54
Neitzel LR, Spencer ZT, Nayak A, Cselenyi CS, Benchabane H, Youngblood CQ, Zouaoui A, Ng V, Stephens L, Hann T, Patton JG, Robbins D, Ahmed Y, Lee E, Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. Mechanism of Development. 2019 156 20-31

2018

Neitzel LR, Broadus MR, Sawyer L, Wallace HA, Merkle JA, Jodoin JN, Sitaram P, Crispi EE, Rork W, Lee LA, Pan D, Gould KL, Page-McCaw A, Lee E, Characterization of a cdc14 null allele in Drosophila melanogaster. Biology Open. 2018 7 (7)
Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed* Y, Lee* E, APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Developmental Cell. 2018 Mar 12; 44 (5) 566-581.e8
Ng* VH, Hang* BI, Sawyer LM, Neitzel LR, Crispi EE, Rose KL, Popay TM, Zhong A, Lee LA, Tansey WP, Huppert S, Lee E, Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. Journal of Cell Science. 2018 Apr 20;
Broadus MR, Lee E, Chemical Screening Using Cell-Free Egg Extract. Cold Spring Harbor Protocols. 2018 Feb 23;

2017

Lu Yuanyuan, Zhao Xiaodi, Liu Qi, Li Cunxi, Graves-Deal Ramona, Cao Zheng, Singh Bhuminder, Franklin Jeffrey, Wang Jing, Hu Huaying, Wei Tainying, Yang Mingli, Yeatman Timothy, Lee Ethan, Saito-Diaz Kenyi, Hinger Scott, Patton James, Chung Christine, Emmrich Stephan, Klusmann Jan-Henning, Fan Daiming, Coffey Robert, IncRNA MIR100HG-derivd miR-100 and miR-125b mediate cetuximab resistance via Wnt/beta-catnenin signaling Nature Medicine. 2017 Nov 11 (23) 1331-1341
Polosukhina D, Love H, Moses H, Lee E, Zent R, Clark P, Pharmacologic Inhibition of ß-catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumo… Oncology Research. 2017 Jul 10;
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ, Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma. Oncogene. 2017 Jul 17;
Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ, Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target … Science Signaling. 2017 Jun 27; 10 (485)
Nlandu-Khodo S, Neelisetty S, Phillips M, Manolopoulou M, Bhave G, May L, Clark PE, Yang H, Fogo AB, Harris RC, Taketo MM, Lee E, Gewin LS, Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD. Journal of the American Society of Nephrology : JASN. 2017 Jul 12;

2016

Wang Z, Tacchelly-Benites O, Yang E, Thorne CA, Nojima H, Lee E, Ahmed Y, Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor … Genetics. 2016 May 203 (1) 269-81
Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y, Wnt pathway activation by ADP-ribosylation. Nature Communications. 2016 May 3; 7 11430
Hyde AS, Hang BI, Lee E, Reconstitution of the Cytoplasmic Regulation of the Wnt Signaling Pathway Using Xenopus Egg Extracts… Methods in Molecular Biology . 2016 1481 101-9
Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert* SS, Lee* E, Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell Reports. 2016 May 31; 15 (9) 1920-9
Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, MacKerell AD, Capobianco AJ, The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigen… Cancer Research. 2016 Jun 15; 76 (12) 3593-603

2015

Bastakoty D, Saraswati S, Cates J, Lee E, Nanney LB, Young PP, Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury. FASEB Journal . 2015 Dec 29 (12) 4881-92
Broadus MR, Yew PR, Hann SR, Lee E, Small-molecule high-throughput screening utilizing Xenopus egg extract. Methods in Molecular Biology . 2015 1263 63-73
Winterbottom EF, Fei DL, Koestler DC, Giambelli C, Wika E, Capobianco AJ, Lee E, Marsit CJ, Karagas MR, Robbins DJ, GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth. EBioMedicine. 2015 Jun 2 (6) 536-43

2014

Hainline SG, Rickmyre JL, Neitzel LR, Lee LA, Lee E, The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex. Biology Open. 2014 3 (7) 669-76
Chen* TW, Broadus* MR, Huppert SS, Lee E, Reconstitution Of β-catenin degradation in Xenopus egg extract. Journal of Visualized Experiments. 2014 (88)
Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ, Pyrvinium attenuates Hedgehog signaling downstream of smoothened. Cancer Research. 2014 Sep 1; 74 (17) 4811-21
Li B, Flaveny CA, Giambelli C, Fei DL, Han L, Hang BI, Bai F, Pei XH, Nose V, Burlingame O, Capobianco AJ, Orton D, Lee E, Robbins DJ, Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal… PloS One. 2014 9 (7) e101969
Sitaram P, Merkle JA, Lee E, Lee LA, Asunder is required for dynein localization and dorsal fate determination during Drosophila oogenesi… Developmental Biology. 2014 Feb 1; 386 (1) 42-52
Wallace HA, Merkle JA, Yu MC, Berg TG, Lee E, Bosco G, Lee LA, TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η. Development. 2014 Mar 141 (6) 1332-41
Murphy AJ, Pierce J, de Caestecker C, Ayers GD, Zhao A, Krebs JR, Saito-Diaz VK, Lee E, Perantoni AO, de Caestecker MP, Lovvorn HN, CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucle… Oncotarget. 2014 Jan 30; 5 (2) 386-402

2013

Tacchelly-Benites O, Wang Z, Yang E, Lee E, Ahmed Y, Toggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. Th… BioEssays. 2013 Dec 35 (12) 1063-70
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E, The way Wnt works: components and mechanism. Growth Factors . 2013 Feb 31 (1) 1-31
Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE, Targeting the Wnt pathway in synovial sarcoma models. Cancer Discovery. 2013 Nov 3 (11) 1286-301
Ferguson JL, Chao WC, Lee E, Friedman KL, The anaphase promoting complex contributes to the degradation of the S. cerevisiae telomerase recrui… PloS One. 2013 8 (1) e55055
Hao J, Ao A, Zhou L, Murphy CK, Frist AY, Keel JJ, Thorne CA, Kim K, Lee E, Hong CC, Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen… Cell Reports. 2013 Sep 12; 4 (5) 898-904
Jodoin JN, Shboul M, Albrecht TR, Lee E, Wagner EJ, Reversade B, Lee LA, The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the… Biology Open. 2013 2 (12) 1390-6
Jodoin JN, Sitaram P, Albrecht TR, May SB, Shboul M, Lee E, Reversade B, Wagner EJ, Lee LA, Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator c… Molecular Biology of the Cell. 2013 Sep 24 (18) 2954-65

2012

Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E, Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorganic & Medicinal Chemistry. 2012 Mar 15; 20 (6) 1869-77
Sitaram P, Anderson MA, Jodoin JN, Lee E, Lee LA, Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila … Development . 2012 Aug 139 (16) 2945-54
Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E, XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Molecular Cell. 2012 Mar 9; 45 (5) 619-28
Jodoin JN, Shboul M, Sitaram P, Zein-Sabatto H, Reversade B, Lee E, Lee LA, Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Molecular Biology of the Cell. 2012 Dec 23 (24) 4713-24

2011

Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E, A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopu… Journal of Biomolecular Screening. 2011 Oct 16 (9) 995-1006
Ni TT, Rellinger EJ, Mukherjee A, Xie S, Stephens L, Thorne CA, Kim K, Hu J, Lee E, Marnett L, Hatzopoulos AK, Zhong TP, Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chemistry & Biology. 2011 Dec 23; 18 (12) 1658-68

2010

Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E, Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nature Chemical Biology. 2010 Nov 6 (11) 829-36
Jernigan* KK, Cselenyi* CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E, Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Science Signaling. 2010 May 11; 3 (121) ra37
Alfaro MP, Vincent A, Saraswati S, Thorne CA, Hong CC, Lee E, Young PP, sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell… The Journal of Biological Chemistry. 2010 Nov 12; 285 (46) 35645-53
Speirs CK, Jernigan KK, Kim SH, Cha YI, Lin F, Sepich DS, DuBois RN, Lee E, Solnica-Krezel L, Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion throu… Development. 2010 Apr 137 (8) 1327-37
Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP, Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeli… PloS One. 2010 5 (11) e15521

2009

Merkle JA, Rickmyre JL, Garg A, Loggins EB, Jodoin JN, Lee E, Wu LP, Lee LA, No poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosoph… Development. 2009 Feb 136 (3) 449-59
Barton CE, Tahinci E, Barbieri CE, Johnson KN, Hanson AJ, Jernigan KK, Chen TW, Lee E, Pietenpol JA, DeltaNp63 antagonizes p53 to regulate mesoderm induction in Xenopus laevis. Developmental Biology. 2009 May 1; 329 (1) 130-9
Anderson MA, Jodoin JN, Lee E, Hales KG, Hays TS, Lee LA, Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. Molecular Biology of the Cell. 2009 Jun 20 (11) 2709-21

2008

Moore AC, Amann JM, Williams CS, Tahinci E, Farmer TE, Martinez JA, Yang G, Luce KS, Lee E, Hiebert SW, Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dep… Molecular and Cellular Biology. 2008 Feb 28 (3) 977-87
Cselenyi* CS, Jernigan* KK, Tahinci E, Thorne CA, Lee LA, Lee E, LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3’s phosph… Proceedings of the National Academy of Sciences, USA. 2008 Jun 10; 105 (23) 8032-7
Alfaro MP, Pagni M, Vincent A, Atkinson J, Hill MF, Cates J, Davidson JM, Rottman J, Lee E, Young PP, The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and… Proceedings of the National Academy of Sciences, USA. 2008 Nov 25; 105 (47) 18366-71

2007

Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E, Lrp6 is required for convergent extension during Xenopus gastrulation. Development . 2007 Nov 134 (22) 4095-106
Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA, The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the… Journal of Cell Science. 2007 Oct 15; 120 (Pt 20) 3565-77

2005

Lee* LA, Lee* E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL, Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regul… Developmental Cell. 2005 Mar 8 (3) 435-42

2004

Tahinci E, Lee E, The interface between cell and developmental biology. Current Opinion in Genetics & Development. 2004 Aug 14 (4) 361-6
Ivanovska I, Lee E, Kwan KM, Fenger DD, Orr-Weaver TL, The Drosophila MOS ortholog is not essential for meiosis. Current Biology . 2004 Jan 6; 14 (1) 75-80

2003

Lee* E, Salic* A, Krüger* R, Heinrich R, Kirschner MW, The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biology. 2003 Oct 1 (1) E10

2001

Pfleger CM, Salic A, Lee E, Kirschner MW, Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes & Development. 2001 Jul 15; 15 (14) 1759-64
Lee E, Salic A, Kirschner MW, Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. The Journal of Cell Biology. 2001 Sep 3; 154 (5) 983-93
Pfleger CM, Lee E, Kirschner MW, Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes & Development. 2001 Sep 15; 15 (18) 2396-407

2000

Salic* A, Lee* E, Mayer L, Kirschner MW, Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xen… Molecular Cell. 2000 Mar 5 (3) 523-32

1996

Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR, Structure of the GDP-Pi complex of Gly203–>Ala gialpha1: a mimic of the ternary product complex of … Structure. 1996 Nov 15; 4 (11) 1277-90

1995

Wall MA, Coleman DE, Lee E, Iñiguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR, The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell. 1995 Dec 15; 83 (6) 1047-58
Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR, Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science. 1995 Nov 10; 270 (5238) 954-60

1994

Lee E, Linder ME, Gilman AG, Expression of G-protein alpha subunits in Escherichia coli. Methods in Enzymology. 1994 237 146-64
Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG, G protein beta gamma subunits. Simplified purification and properties of novel isoforms. The Journal of Biological Chemistry. 1994 Feb 11; 269 (6) 4388-95
Coleman DE, Lee E, Mixon MB, Linder ME, Berghuis AM, Gilman AG, Sprang SR, Crystallization and preliminary crystallographic studies of Gi alpha 1 and mutants of Gi alpha 1 in … Journal of Molecular Biology. 1994 May 13; 238 (4) 630-4
Coleman* DE, Berghuis* AM, Lee* E, Linder ME, Gilman AG, Sprang SR, Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science . 1994 Sep 2; 265 (5177) 1405-12
Kleuss C, Raw AS, Lee E, Sprang SR, Gilman AG, Mechanism of GTP hydrolysis by G-protein alpha subunits. Proceedings of the National Academy of Sciences, USA. 1994 Oct 11; 91 (21) 9828-31

1990

Doyle KE, Kovalick GE, Lee E, Beckingham K, Drosophila melanogaster contains a single calmodulin gene. Further structure and expression studies. Journal of Molecular Biology. 1990 Jun 20; 213 (4) 599-605

1989

Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RG, Goldstein JL, Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins. The Journal of Biological Chemistry. 1989 May 15; 264 (14) 8260-70