{"id":221,"date":"2022-09-30T21:12:01","date_gmt":"2022-09-30T21:12:01","guid":{"rendered":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/?page_id=221"},"modified":"2026-05-04T08:30:31","modified_gmt":"2026-05-04T08:30:31","slug":"221-2","status":"publish","type":"page","link":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/221-2\/","title":{"rendered":"Publications"},"content":{"rendered":"\n\n \"\"Saturation mutagenesis of a predicted ancestral Syk-family kinase<\/strong>
\nHelen T Hobbs, Neel H Shah, Sophie R Shoemaker, Jeanine F Amacher, Susan Marqusee, and John Kuriyan\n

Protein Science<\/em>\u00a02022 31(10):e4411. \u2003doi: 10.1002\/pro.4411<\/a><\/p>\n

BioR\u03c7iv 2022.04.24.489292; doi: https:\/\/doi.org\/10.1101\/2022.04.24.489292<\/p>\n \n

\"\"<\/a>A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane<\/strong>
Chun-Wei Lin, Laura M Nocka, Brittany L. Stinger, Joseph B DeGrandchamp, LJ Nugent Lew, Steven Alvarez, Henry T Phan, Yasushi Kondo, John Kuriyan and Jay T GrovesProc Natl Acad Sci<\/em>\u00a0USA 2022 119(19):e2122531119\u2003https:\/\/doi.org\/10.1073\/pnas.2122531119<\/a>BioR\u03c7iv 2021.12.12.472247; doi: https:\/\/doi.org\/10.1101\/2021.12.12.472247<\/p>\n \n

\"\"\"\"<\/p>\nA saturation-mutagenesis analysis of the interplay between stability and activation in Ras<\/strong>
\nFrank Hidalgo, Laura M Nocka, Neel H Shah, Kent Gorday, Naomi R Latorraca, Pradeep Bandaru, Sage Templeton, David Lee, Deepti Karandur, Jeffery G Pelton, Susan Marqusee, David E Wemmer and John Kuriyan\neLife<\/em>\u00a02022 11:e76595
\ndoi:\u00a0https:doi.org\/10.7554\/eLife.76595<\/a>\n \n

2021<\/h2>\n

\"\"A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor<\/strong>
Yongjian Huang, Jana Ognjenovi\u0107, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam and John KuriyaneLife<\/em>\u00a02021 10:e73218 \u2003doi:\u00a010.7554\/eLife.73218<\/a>BioR\u03c7iv 2020.12.08.417006; doi: https:\/\/doi.org\/10.1101\/2020.12.08.417006<\/p>\n \n

\"\"Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases<\/strong>
Helen T Hobbs, Neel H Shah, Jean M Badroos, Christine L Gee, Susan Marqusee and John KuriyanProtein Science<\/em>\u00a02021 30:2373-2384 \u2003Epub October 3 \u2003doi:\u00a010.1002\/pro.4199<\/a>BioR\u03c7iv 2021.07.20.453126;
doi:https:\/\/doi.org\/10.1101\/2021.07.20.453126<\/p>\n \n \"\"Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction<\/strong>
\nSubu Subramanian, Kent Gorday, Kendra Marcus, Matthew R. Orellana, Peter Ren, Xiao Ran Luo, Mike O’Donnell and John Kuriyan\n

2021 10:e66181 \u2003doi:\u00a010.7554\/eLife.66181<\/a><\/p>\nBioR\u03c7iv 2020.12.31.424921;
\ndoi:https:\/\/doi.org\/10.1101\/2020.12.31.424921\n \n

2020<\/h2>\n

\"\"Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase<\/strong>
Deepti Karandur*, Moitrayee Bhattacharyya*, Zijie Xia*, Young Kwang Lee, Serena Muratcio\u011flu, Darren McAffee, Ethan D McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams and John KuriyaneLife<\/em>\u00a02020;9:e57784 \u2003doi:\u00a010.7554\/eLife.57784<\/a>
BioR\u03c7iv 2020.04.15.043067; doi: https:\/\/doi.org\/10.1101\/2020.04.15.043067<\/p>\n \n

\"\"<\/strong><\/p>\nCRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks<\/strong>
\nJoshua C Cofsky, Deepti Karandur, Carolyn J Huang, Isaac P Witte, John Kuriyan and Jennifer A Doudna\n

eLife<\/em>\u00a02020;9:e55143 \u2003doi:\u00a010.7554\/eLife.55143<\/a><\/p>\n \n

\"\"<\/strong><\/p>\nFlexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation<\/strong>
\nMoitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcio\u011flu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T Groves and John Kuriyan\n

eLife<\/em>\u00a02020;9:e53670 \u2003doi:\u00a010.7554\/eLife.53670<\/a><\/p>\n \n

2019<\/h2>\n

\"\" \"\"<\/p>\nCryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases<\/strong>
\nYasushi Kondo*, Jana Ognjenovi\u0107*, Saikat Banerjee, Deepti Karandur, Alan Merk, Kayla Kulhanek, Kathryn Wong, Jeroen P. Roose, Sriram Subramaniam and John Kuriyan\nScience<\/em>\u00a02019 366:109-115 \u2003Epub Sep 19
\ndoi:\u00a0https:\/\/www.science.org\/doi\/10.1126\/science.aay0543<\/a>\n \n

\"\" \"\"Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization<\/strong>
Jean K Chung*, Laura M Nocka*, Aubrianna Decker, Qi Wang, Theresa A Kadlecek, Arthur Weiss, John Kuriyan and Jay T. GrovesProc Natl Acad Sci USA<\/em>\u00a02019 116(22):10798-10803
doi:\u00a0https:\/\/doi.org\/10.1101\/284000<\/a>BioR\u03c7iv 284000; doi: https:\/\/doi.org\/10.1101\/284000<\/p>\n \n \"\"Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+\/Calmodulin-dependent protein kinase II<\/strong>
\nEthan D McSpadden, Zijie Xia, Chris C Chi, Anna C Susa, Neel H Shah, Christine L Gee, Evan R Williams and John Kuriyan\n

Protein Science<\/em>\u00a02019 28:1071-1082 \u2003Epub Apr 3 \u2003doi:\u00a0https:\/\/doi.org\/10.1002\/pro.3614<\/a><\/p>\n

BioR\u03c7iv 536094; doi: https:\/\/doi.org\/10.1101\/536094<\/p>\n \n

2018<\/h2>\n \"\"Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites<\/strong>
\nAaron C Cantor, Neel H Shah and John Kuriyan\nProc Natl Acad Sci USA<\/em>\u00a02018 115(31):E7303-E7312 \u2003Epub July 16
\ndoi:\u00a0https:\/\/doi.org\/10.1073\/pnas.1803598115<\/a>\n

BioR\u03c7iv 273516; doi: https:\/\/doi.org\/10.1101\/273516<\/p>\n \n \"\"Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen<\/strong>
\nNeel H Shah, Mark L\u00f6bel, Arthur Weiss and John Kuriyan\n

eLife<\/em>\u00a02018;7:e35190 \u2003doi:\u00a0https:\/\/doi.org\/10.7554\/eLife.35190<\/a><\/p>\n

BioR\u03c7iv 250753; doi: https:\/\/doi.org\/10.1101\/250753<\/p>\n \n \"\"Phosphorylation Control of the Ubiquitin Ligase Cbl is Conserved in Choanoflagellates<\/strong>
\nJeanine F Amacher, Helen T Hobbs, Aaron C Cantor, Lochan Shah, Marco-Jose Rivero,
\nSarah A Mulchand and John Kuriyan\n

Protein Science<\/em>\u00a02018 27(5):923-932. Epub 2018 Mar 2. \u2003doi:\u00a0https:\/\/doi.org\/10.1002\/pro.3397<\/a><\/p>\n \n

2017<\/h2>\n

\"\"\"\"<\/strong>A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1<\/strong>
Yvonne Vercoulen*, Yasushi Kondo*, Jeffrey S Iwig*, Axel B. Janssen, Katharine A White, Mojtaba Amini, Diane L Barber, John Kuriyan and Jeroen P RooseeLife<\/em>\u00a02017;6:e29002. \u2003doi:\u00a0https:\/\/doi.org\/1<\/a><\/p>\n \n

\"\" \"\"<\/p>\nMultiple interactions between an Arf\/GEF complex and charged lipids determine activation kinetics on the membrane<\/strong>
\nDeepti Karandur*, Agata Nawrotek*, John Kuriyan and Jacqueline Cherfils\nProc Natl Acad Sci U S A<\/em>\u00a02017 Oct 24;114(43):11416-11421. Epub 2017 Sep 18.
\ndoi:\u00a0https:\/\/doi.org\/10.1073\/pnas.1707970114<\/a>\n \n

\"\"<\/p>\nDeconstruction of the Ras switching cycle through saturation mutagenesis<\/strong>
\nPradeep Bandaru, Neel H Shah, Moitrayee Bhattacharyya, John P Barton, Yasushi Kondo, Joshua C Cofsky, Christine L Gee, Arup K Chakraborty, Tanja Kortemme, Rama Ranganathan and John Kuriyan\n

eLife<\/em>\u00a02017;6:e27810 \u2003doi:\u00a0https:\/\/doi.org\/10.7554\/eLife.27810<\/a><\/p>\n \n \"\"Identification of inhibitors of the association of ZAP-70 with the T cell receptor<\/strong>
\nby high-throughput screen<\/strong>
\nPatrick R Visperas, Christopher G Wilson, Jonathan A Winger, Qingrong Yan, Kevin Lin, Michelle R Arkin, Arthur Weiss and John Kuriyan\nSLAS Discov.<\/em>\u00a02017 Mar 1;22(3):324-331. \u2003Epub 2016 Dec 13
\ndoi:\u00a0https:\/\/doi.org\/10.1177\/1087057116681407<\/a>\n \n

2016<\/h2>\n

\"\" \"\"<\/strong><\/p>\nMolecular basis for multimerization in the activation of the epidermal growth factor receptor<\/strong>
\nYongjian Huang*, Shashank Bharill*, Deepti Karandur, Sean M Peterson, Morgan Marita, Xiaojun Shi, Megan J Kaliszewski, Adam W Smith, Ehud Y Isacoff and John Kuriyan\neLife<\/em>\u00a02016 Mar 28;5:e14107.
\ndoi: 10.7554\/eLife.14107.\n \n

\"\"<\/strong>\u00a0Crystal Structure of a Ube2S-Ubiquitin Conjugate<\/strong>
Sonya Lorenz, Moitrayee Bhattacharyya, Christian Feiler, Michael Rape and John KuriyanPLoS One<\/em>\u00a02016 11(2):e0147550. \u2003doi: 10.1371\/journal.pone.0147550<\/a><\/p>\n \n

2015<\/h2>\n \"\"Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220)<\/strong>
\nJulie A. Zorn, Qi Wang, Eric Fujimura, Tiago Barros and John Kuriyan\n

PLoS One 2015<\/em>\u00a010(4):e0121177. \u2003doi: 10.1371\/journal.pone.0121177<\/p>\n \n

\"\" \"\"<\/strong>Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor<\/strong>
Erika Kovacs*, Rahul Das*, Qi Wang, Timothy S. Collier, Aaron Cantor, Yongjian Huang, Kathryn Wong, Amar Mirza, Tiago Barros, Patricia Grob, Natalia Jura, Ron Bose and John KuriyanMol Cell Biol.<\/em>\u00a02015 35(17):3083-102.\u00a0 \u00a0 \u00a0 \u00a0doi: 10.1128\/MCB.00248-15.<\/p>\n \n \"\"Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity<\/strong>
\nSonja Lorenz, Patricia Deng, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan\n

Biochem. J.<\/em>\u00a02015, 468(2):283-91\u2003doi: 10.1042\/BJ20141492<\/p>\n \n \"\"Autoinhibition of Bruton’s tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate<\/strong>
\nQi Wang, Erik M Vogan, Laura M Nocka, Connor E Rosen, Julie A Zorn, Stephen C Harrison and John Kuriyan\n

eLife<\/em>\u00a02015 10.7554\/eLife.06074 \u2003doi: 10.7554\/eLife.06074<\/p>\n \n \"\"Modification by covalent reaction or oxidation of cysteine residues in the Tandem-SH2 Domains of ZAP-70 and Syk Can Block Phosphopeptide Binding<\/strong>
\nPatrick R Visperas, Jonathan A Winger, Timothy M Horton, Neel H Shah, Diane J Aum, Alyssa Tao, Tiago Barros, Qingrong Yan, Christopher G Wilson, Michelle R Arkin, Arthur Weiss and John Kuriyan\n

Biochem J.<\/em>\u00a02015 465(1):149-61 \u2003doi: 10.1042\/BJ20140793<\/p>\n \n

2014<\/h2>\n \"\"Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity<\/strong>
\nMargaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves and John Kuriyan\n

eLife<\/em>\u00a02014 3:e01610.\u2003doi: 10.7554\/eLife.01610<\/p>\n \n

2013<\/h2>\n \"\"Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1<\/strong>
\nJeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose and John Kuriyan\n

eLife<\/em>\u00a02013 2:e00813.\u2003doi: 10.7554\/eLife.00813<\/p>\n \n

\"\" \"\"<\/p>\nA structural role for the PHP domain in\u00a0E. coli<\/em>\u00a0DNA polymerase III<\/strong>
\nTiago Barros*, Joel Guenther*, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O’Donnell, John Kuriyan and Meindert H. Lamers\nBMC Struct Biol.<\/em>\u00a02013 13:8.
\ndoi: 10.1186\/1472-6807-13-8\n \n

\"\"<\/strong><\/p>\n

 <\/p>\nA highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation<\/strong>
\nKate Engel, Tomoaki Sasaki, Qi Wang and John Kuriyan\n

Biochem J.<\/em>\u00a02013 453(3):337-44. \u2003doi: 10.1042\/BJ20130537<\/p>\n \n \"\"Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker<\/strong>
\nQingrong Yan, Tiago Barros, Patrick R Visperas, Sebastian Deindl, Theresa A Kadlecek, Arthur Weiss and John Kuriyan\n

Mol Cell Biol.<\/em>\u00a02013 33(11):2188-201. \u2003doi: 10.1128\/MCB.01637-12<\/p>\n \n

\"\" \"\"Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor<\/strong>
Nicholas F Endres*, Rahul Das*, Adam W Smith*, Anton Arkhipov, Erika Kovacs, Yongjian Huang, Jeffrey G Pelton, Yibing Shan, David E Shaw, David E Wemmer, Jay T Groves and John KuriyanCell<\/em>\u00a02013 152(3):543-56.\u00a0 \u00a0 \u00a0 \u00a0doi: 10.1016\/j.cell.2012<\/p>\n \n

2011<\/h2>\n \"\" \"\"
\nHow a DNA polymerase clamp loader opens a sliding clamp<\/strong>
\nBrian A Kelch*, Debora L Makino*, Michael O’Donnell and John Kuriyan\nScience<\/em>\u00a02011 334(6063):1675-80.
\ndoi: 10.1126\/science.1211884\n \n \"\"A mechanism for tunable autoinhibition in the structure of a human Ca2+\/calmodulin-dependent kinase II holoenzyme<\/strong>
\nLuke H Chao, Margaret M Stratton, Il-Hyung Lee, Oren S Rosenberg, Joshua Levitz, Daniel J Mandell, Tanja Kortemme, Jay T Groves, Howard Schulman and John Kuriyan\n

Cell<\/em>\u00a02011 146(5):732-45. \u2003doi: 10.1016\/j.cell.2011.07.038<\/p>\n \n \"\"The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2<\/strong>
\nKatherine E Wickliffe*, Sonja Lorenz*, David E Wemmer, John Kuriyan and Michael Rape\n

Cell<\/em>\u00a02011 144(5):769-81. \u2003doi: 10.1016\/j.cell.2011.01.035<\/p>\n \n

2010<\/h2>\n

\"\"<\/strong>\u00a0Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation<\/strong>
Luke H Chao, Patricia Pellicena, Sebastian Deindl, Lauren A Barclay, Howard Schulman and John KuriyanNat Struct Mol Biol.<\/em>\u00a02010 17(3):264-72. \u2003doi: 10.1038\/nsmb.1751<\/p>\n \n \"\"Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless<\/strong>
\nJodi Gureasko, Olga Kuchment, Debora Lika Makino, Holger Sondermann, Dafna Bar-Sagi and John Kuriyan\n

Proc Natl Acad Sci USA<\/em>. 2010 107(8):3430-5. \u2003doi: 10.1073\/pnas.0913915107<\/p>\n \n \"\"Analysis of the role of PCNA-DNA contacts during clamp loading<\/strong>
\nRandall McNally, Gregory D Bowman, Eric R Goedken, Mike O’Donnell and John Kuriyan\n

BMC Struct. Biol.\u00a0<\/em>2010 10:3. \u2003doi: 10.1186\/1472-6807-10-3<\/p>\n \n

2009<\/h2>\n \"\"Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3<\/strong>
\nNatalia Jura, Yibing Shan, Xiaoxian Cao, David Shaw and John Kuriyan\n

Proc Natl Acad Sci USA<\/em>\u00a02009 106(51):21608-13. \u2003doi: 10.1073\/pnas.0912101106<\/p>\n \n \"\"Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response<\/strong>
\nSebastian Deindl, Theresa A Kadlecek, Xiaoxian Cao, John Kuriyan and Arthur Weiss\n

Proc Natl Acad Sci USA<\/em>\u00a02009 106(49):20699-20704. \u2003doi:10.1073\/pnas.0911512106<\/p>\n \n

\"\"<\/strong>The tyrosine kinase Csk dimerizes through its SH3 domain<\/strong>
Nicholas M. Levinson, Patrick R. Visperas and John KuriyanPLoS One<\/em>\u00a02009 4(11):e7683. \u2003doi: 10.1371\/journal.pone.0007683<\/p>\n \n \"\"Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment<\/strong>
\nNatalia Jura, Nicholas F Endres, Kate Engel, Sebastian Deindl, Rahul Das, Meindert H Lamers, David E Wemmer, Xuewu Zhang and John Kuriyan\n

Cell<\/em>\u00a02009 137(7):1293-307. \u2003doi: 10.1016\/j.cell.2009.04.025<\/p>\n \n \"\"The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex<\/strong>
\nKyle R Simonetta, Steven L Kazmirski, Eric R Goedken, Aaron J Cantor, Brian A Kelch, Randall McNally, Steven N Seyedin, Debora L Makino, Mike O’Donnell and John Kuriyan\n

Cell<\/em>\u00a02009 137(4):659-71. \u2003doi: 10.1016\/j.cell.2009.03.044<\/p>\n \n \"\"Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations<\/strong>
\nMarkus A Seeliger, Pratistha Ranjitkar, Corynn Kasap, Yibing Shan, David E Shaw, Neil P Shah, John Kuriyan and Dustin J Maly\n

Cancer Res.<\/em>\u00a02009 69(6):2384-92. \u2003doi: 10.1158\/0008-5472.CAN-08-3953<\/p>\n \n

\"\"<\/strong>\u00a0The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)<\/strong>
Jonathan A Winger, Oliver Hantschel, Giulio Superti-Furga and John KuriyanBMC Struct Biol.<\/em>\u00a02009 9:7. \u2003doi: 10.1186\/1472-6807-9-7<\/p>\n \n \"\"Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1<\/strong>
\nTanya S Freedman, Holger Sondermann, Olga Kuchment, Gregory D Friedland, Tanja Kortemme and John Kuriyan\n

Structure<\/em>\u00a02009 17(1):41-53. \u2003doi: 10.1016\/j.str.2008.11.004<\/p>\n \n

2008<\/h2>\n \"\"The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase<\/strong>
\nJonathan A Winger, Emily R Derbyshire, Meindert H Lamers, Michael A Marletta and John Kuriyan\n

BMC Struct Biol.<\/em>\u00a02008 8:42. \u2003doi: 10.1186\/1472-6807-8-42<\/p>\n \n \"\"Membrane-dependent signal integration by the Ras activator Son of sevenless<\/strong>
\nJodi Gureasko, William J Galush, Sean Boykevisch, Holger Sondermann, Dafna Bar-Sagi, Jay T Groves and John Kuriyan\n

Nat Struct Mol Biol.<\/em>\u00a02008 15(5):452-61. \u2003doi: 10.1038\/nsmb.1418<\/p>\n \n \"\"Structural Basis for the Recognition of c-Src by Its Inactivator Csk<\/strong>
\nNicholas M Levinson, Markus A Seeliger, Philip A Cole and John Kuriyan\n

Cell<\/em>\u00a02008 134(1):124-34. \u2003doi: 10.1016\/j.cell.2008.05.051<\/p>\n \n

2007<\/h2>\n

\"\"<\/strong>\u00a0Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface<\/strong>
Xuewu Zhang, Kerry A. Pickin, Ron Bose, Natalia Jura, Philip A. Cole, and John KuriyanNature<\/em>\u00a02007 450(7170):741-4<\/p>\n \n \"\"Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70<\/strong>
\nSebastian Deindl, Theresa A Kadlecek, Tomas Brdicka, Xiaoxian Cao, Arthur Weiss and John Kuriyan\n

Cell<\/em>\u00a02007 129(4):735-46<\/p>\n \n \"\"c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl\/c-Kit Conformation and a Distributed Thermodynamic Penalty<\/strong>
\nMarkus A Seeliger, Bhushan Nagar, Filipp Frank, Xiaoxian Cao, M Nidanie Henderson and John Kuriyan\n

Structure<\/em>\u00a02007 15(3):299-311<\/p>\n \n

2006<\/h2>\n \"\"Protein-protein Interactions in the Allosteric Regulation of Protein Kinases<\/strong>
\nPatricia Pellicena and John Kuriyan\n

Curr Opin Struct Biol.<\/em>\u00a02006 16(6):702-9<\/p>\n \n

\"\" \"\"A Ras-induced Conformational Switch in the Ras Activator Son of Sevenless
Tanya S Freedman*, Holger Sondermann*, Gregory D Friedland, Tanja Kortemme, Dafna Bar-Sagi, Susan Marqusee and John KuriyanProc Natl Acad Sci USA<\/em>\u00a02006 103(45):16692-7<\/p>\n \n

\"\"<\/strong>Crystal Structure of the Catalytic \u03b1 Subunit of\u00a0E. coli<\/em>\u00a0Replicative DNA Polymerase III<\/strong>
Meindert H Lamers, Roxana E Georgescu, Sang-Gyu Lee, Mike O’Donnell and John KuriyanCell<\/em>\u00a02006 126(5):881-92<\/p>\n \n

\"\"<\/strong>\u00a0A Dimeric Kinase Assembly Underlying Autophosphorylation in the p21 Activated Kinases<\/strong>
Michelle Pirruccello, Holger Sondermann, Jeffrey G Pelton, Patricia Pellicena, Andr\u00e9 Hoelz, Jonathan Chernoff, David E Wemmer and John KuriyanJ Mol Biol.<\/em>\u00a02006 361(2):312-26<\/p>\n \n

\"\"<\/strong>\u00a0An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor<\/strong>
Xuewu Zhang, Jodi Gureasko, Kui Shen, Philip A Cole and John KuriyanCell<\/em>\u00a02006 125(6):1137-49<\/p>\n \n

\"\" \"\"<\/p>\nA Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain<\/strong>
\nNicholas M Levinson*, Olga Kuchment*, Kui Shen, Matthew A Young, Michael Koldobskiy, Martin Karplus, Philip A Cole and John Kuriyan\n

PLoS Biol.<\/em>\u00a02006 4(5):e144<\/p>\n \n \"\"Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680<\/strong>
\nMatthew A Young, Neil P Shah, Luke H Chao, Markus Seeliger, Zdravko V Milanov, William H Biggs, III, Daniel K Treiber, Hitesh K Patel, Patrick P Zarrinkar, David J Lockhart, Charles L Sawyers and John Kuriyan\n

Cancer Res<\/em>\u00a02006 66(2): 1007-14. \u2003doi: 10.1158\/0008-5472.CAN-05-2788<\/p>\n \n \"\"Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase<\/strong>
\nBhushan Nagar, Oliver Hantschel, Markus Seeliger, Jason M Davies, William I Weis, Giulio Superti-Furga and John Kuriyan\n

Mol Cell.<\/em>\u00a02006 21(6):787-98<\/p>\n \n \"\"Oligomerization states of the association domain and the holoenyzme of Ca2+\/CaM kinase II<\/strong>
\nOren S. Rosenberg, Sebastian Deindl, Luis R Comolli, Andr\u00e9 Hoelz, Kenneth H Downing, Angus C Nairn and John Kuriyan\n

FEBSJ<\/em>\u00a02006\u00a0 273:682-694. \u2003doi: 10.1111\/j.1742-4658.2005.05088.x<\/p>\n \n \"\"Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium<\/strong>
\nMaria A Argiriadi, Eric R Goedken, Irina Bruck, Mike O’Donnell and John Kuriyan\n

BMC Struct Biol.<\/em>\u00a02006 6:2<\/p>\n \n

2005<\/h2>\n \"\"Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme<\/strong>
\nOren S. Rosenberg, Sebastian Deindl, Rou-Jia Sung, Angus C. Nairn and John Kuriyan\n

Cell<\/em>\u00a02005 123(5):849-60<\/p>\n \n

\"\"High yield bacterial expression of active c-Abl and c-Src tyrosine kinases<\/strong>Markus A. Seeliger, Matthew Young, M. Nidanie Henderson, Patricia Pellicena, David S. King, Arnold M. Falick and John KuriyanProtein Sci.<\/em>\u00a02005 14(12):3135-9<\/p>\n \n \"\"Computational Docking and Solution X-ray Scattering Predict a Membrane-interacting Role for the Histone Domain of the Ras-activator Son of Sevenless<\/strong>
\nHolger Sondermann, Bhushan Nagar, Dafna Bar-Sagi and John Kuriyan\n

Proc Natl Acad Sci USA<\/em>\u00a02005 102(46):16632-7<\/p>\n \n \"\"Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen<\/strong>
\nSteven L. Kazmirski, Yanxiang Zhao, Gregory D. Bowman, Mike O’Donnell and John Kuriyan\n

Protein Sci.<\/em>\u00a02005 14(12):3135-9<\/p>\n \n \"\"Mapping the interaction of DNA with the\u00a0Escherichia coli<\/em>\u00a0DNA polymerase clamp loader complex<\/strong>
\nEric R Goedken, Steven L Kazmirski, Gregory D Bowman, Mike O’Donnell and John Kuriyan\n

Nat Struct Mol Biol<\/em>\u00a02005 12(2):183-90<\/p>\n \n

2004<\/h2>\n

\"\"\"\" <\/strong>Structural analysis of the inactive state of the\u00a0Escherichia coli<\/em>\u00a0DNA polymerase clamp-loader complex<\/strong>
Steven L. Kazmirski*, Marjetka Podobnik*, Tanya F. Weitze, Mike O’Donnell and John KuriyanProc Natl Acad Sci USA<\/em>\u00a02004 101(48):16750-5<\/p>\n \n

\"\" \"\"Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless<\/strong>
Holger Sondermann*, Stephen M. Soisson*, Sean Boykevisch, Shao-Song Yang, Dafna Bar-Sagi and John KuriyanCell<\/em>\u00a02004 119(3):393-405<\/p>\n \n

\"\"Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases<\/strong>
Patricia Pellicena, David S. Karow, Elizabeth M. Boon, Michael A. Marletta and John KuriyanProc Natl Acad Sci USA<\/em>. 2004 101(35):12854-9<\/p>\n \n \"\"Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex<\/strong>
\nGregory D. Bowman, Mike O’Donnell and John Kuriyan\n

Nature<\/em>\u00a02004 429(6993):724-30<\/p>\n \n

\"\"Fluorescence Measurements on the\u00a0E. coli<\/em>\u00a0DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding<\/strong><\/p>\n

Eric R. Goedken, Marcia Levitus, Aaron Johnson, Carlos Bustamante, Mike O’Donnell and John Kuriyan<\/p>\n

J Mol Biol.<\/i>\u00a02004 336(5):1047-59<\/p>\n \n \"\"Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex<\/strong>
\nJacqueline M. Gulbis, Steven L. Kazmirski, Jeff Finkelstein, Zvi Kelman, Mike O’Donnell and John Kuriyan\n

Eur J Biochem.<\/em>\u00a02004 271(2):439-49<\/p>\n \n

2003<\/h2>\n \"\"Tandem Histone Folds in the Structure of the N-terminal Segment of the Ras Activator Son of Sevenless<\/strong>
\nHolger Sondermann, Stephen M. Soisson, Dafna Bar-Sagi, and John Kuriyan\n

Structure 2003<\/em>\u00a011(12):1583-93<\/p>\n \n

\"\"<\/strong>Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+\/Calmodulin-Dependent Kinase II<\/strong>
Andre Hoelz, Angus C. Nairn and John KuriyanMol Cell.<\/em>\u00a02003 11(5):1241-51<\/p>\n \n

\"\" \"\" <\/strong><\/p>\nStructural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS<\/strong>
\nS. Mariana Margarit, Holger Sondermann, Brian E. Hall, Bhushan Nagar, Andre Hoelz, Michelle Pirruccello, Dafna Bar-Sagi, and John Kuriyan\n

Cell<\/em>\u00a02003 112(5):685-95<\/p>\n \n \"\"Nucleotide-Induced Conformational Changes in an Isolated\u00a0Escherichia coli<\/em>\u00a0DNA Polymerase III Clamp Loader Subunit<\/strong>
\nMarjetka Podobnik, Tanya F. Weitze, Mike O’Donnell and John Kuriyan\n

Structure<\/em>\u00a02003 11(3):253-63<\/p>\n \n \"\"Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase<\/strong>
\nNagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J\n

Cell<\/em>\u00a02003 112(6):859-71<\/p>\n \n

\"\"A Myristoyl\/Phosphotyrosine Switch Regulates c-Abl<\/strong><\/p>\n

Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G<\/p>\n

Cell<\/i>\u00a02003 112(6):845-57<\/p>\n \n

\"\" \"\"<\/strong><\/p>\n

Reinterpretation of the Dimerization Interface of the N-terminal Domains of STATs<\/strong><\/p>\n

Xiaomin Chen, Rashna Bhandari, Uwe Vinkemeier, Focco van den Akker, James E. Darnell Jr. and John Kuriyan<\/p>\n

Protein Sci.<\/em>\u00a02003 12(2):361-5<\/p>\n \n

2002<\/h2>\n

\"\"<\/strong>\u00a0Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and STI571<\/strong>
Bhushan Nagar, William Bornmann, Patricia Pellicena, Thomas Schindler, Darren Veach, W. Todd Miller, Bayard Clarkson and John KuriyanCancer Res.<\/em>\u00a02002 62(15):4236-43<\/p>\n \n

2001<\/h2>\n

\"\"<\/strong>\u00a0The TGF Receptor Activation Process: An Inhibitor- to Substrate-Binding Switch<\/strong>
Morgan Huse, Tom W. Muir, Lan Xu, Ye-Guang Chen, John Kuriyan and Joan Massagu\u00e9Mol Cell.<\/em>\u00a02001 8(3):671-82<\/p>\n \n \"\"Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of\u00a0E. coli<\/em>\u00a0DNA Polymerase III<\/strong>
\nDavid Jeruzalmi, Olga Yurieva, Yanxiang Zhao, Matthew Young, Jelena Stewart, Manju Hingorani, Mike O’Donnell and John Kuriyan\n

Cell<\/em>\u00a02001 106(4):417-28<\/p>\n \n \"\"Crystal Structure of the Processivity Clamp Loader Gamma Complex of\u00a0E. coli<\/em>\u00a0DNA Polymerase III<\/strong>
\nDavid Jeruzalmi, Mike O’Donnell and John Kuriyan\n

Cell<\/em>\u00a02001 106(4):429-441<\/p>\n \n\n","protected":false},"excerpt":{"rendered":"

Saturation mutagenesis of a predicted ancestral Syk-family kinase Helen T Hobbs, Neel H Shah, Sophie R Shoemaker, Jeanine F Amacher, Susan Marqusee, and John Kuriyan Protein Science\u00a02022 31(10):e4411. \u2003doi: 10.1002\/pro.4411 BioR\u03c7iv 2022.04.24.489292; doi: https:\/\/doi.org\/10.1101\/2022.04.24.489292 A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membraneChun-Wei Lin, Laura […]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"jetpack_post_was_ever_published":false,"footnotes":""},"tags":[],"class_list":["post-221","page","type-page","status-publish","hentry"],"acf":[],"ACF":{"topper_style":"default","topper_overline":"","topper_title":"","topper_intro":"","default_topper_background_type":"none","footer_style":"standard","recirculation_style":"none","nav_menu":"","nav_menu_secondary":"no","page_style_option":"details","page_theme_option":"light","page_class_name":"","page_jumplinks_option":"no"},"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/PefwOa-3z","_links":{"self":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/pages\/221","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/comments?post=221"}],"version-history":[{"count":170,"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/pages\/221\/revisions"}],"predecessor-version":[{"id":1424,"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/pages\/221\/revisions\/1424"}],"wp:attachment":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/media?parent=221"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/kuriyan-lab\/wp-json\/wp\/v2\/tags?post=221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}