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Jacobson Lab

TRP channels of the pancreatic beta cell.

AUTHORS

Jacobson DAD A , Philipson LH L H . Handbook of experimental pharmacology. 2007 ; (179). 409-24

ABSTRACT

Orchestrated ion fluctuations within pancreatic islets regulate hormone secretion and maybe essential to processes such as apoptosis. A diverse set of ion channels allows for islet cells to respond to a variety of signals and dynamically regulate hormone secretion and glucose homeostasis (reviewed by Houamed et al. 2004). This chapter focuses on transient receptor potential (TRP)-related channels found within the beta cells of the islet and reviews their roles in both insulin secretion and apoptosis.