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Jacobson Lab

TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.

AUTHORS

Vierra NCNicholas C , Dickerson MT Matthew T , Jordan KL Kelli L , Dadi PK Prasanna K , Kadare KA Ketaki A , Altman MK Molly K , Milian SC Sarah C , Jacobson DA David A . Molecular metabolism. 2018 1 31; ().

ABSTRACT

Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells remains unknown. We previously determined that in β-cells, K+ flux through endoplasmic reticulum (ER)-localized TALK-1 channels enhances ER Ca2+ leak, modulating Ca2+ handling and insulin secretion. As glucose amplification of islet somatostatin release relies on Ca2+-induced Ca2+ release (CICR) from the δ-cell ER, we investigated whether TALK-1 modulates δ-cell Ca2+ handling and somatostatin secretion.