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Publications

2025

Yagan M, Najam S, Hu R, Wang Y, Dickerson MT, Dadi PK, Xu Y, Simmons AJ, Stein R, Adams CM, Jacobson DA, Lau KS, Liu Q, Gu G, Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid Diabetes. 2025 74 (5) 838-849

2024

Graff SM, Nakhe AY, Dadi PK, Dickerson MT, Dobson JR, Zaborska KE, Ibsen CE, Butterworth RB, Vierra NC, Jacobson DA, TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet Cell reports. 2024 Jan 10; 43 (1) 113673
Nakhe AY, Dadi PK, Kim J, Dickerson MT, Behera S, Dobson JR, Shrestha S, Cartailler JP, Sampson L, Magnuson MA, Jacobson DA, The MODY-associated L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults eLife. 2024 May 3; 12
Dobson JR, Jacobson DA, Disrupted Endoplasmic Reticulum Ca Handling: A Harβinger of β-Cell Failure Biology. 2024 May 25; 13 (6)
Stauffer PE, Brinkley J, Jacobson DA, Quaranta V, Tyson DR, Purinergic Ca Signaling as a Novel Mechanism of Drug Tolerance in BRAF-Mutant Melanoma Cancers. 2024 Jun 30; 16 (13)

2023

Nakhe AY, Dadi PK, Kim J, Shrestha S, Cartailler JP, Sampson L, Magnuson MA, Jacobson DA, The MODY-associated TALK-1 L114P mutation causes islet α-cell overactivity and β-cell inactivity resulting in transient neonatal diabetes and glucose dyshomeostasis in adults bioRxiv : the preprint server for biology. 2023 Jul 26;
Nakhe AY, Jacobson DA, IPRs puff along: A SNAPpy dance with IP and Ca The Journal of biological chemistry. 2023 Feb 10; 299 (3) 103010

2022

Zaborska KE, Jordan KL, Thorson AS, Dadi PK, Schaub CM, Nakhe AY, Dickerson MT, Lynch JC, Weiss AJ, Dobson JR, Jacobson DA, Liraglutide increases islet Ca oscillation frequency and insulin secretion by activating hyperpolarization-activated cyclic nucleotide-gated channels Diabetes, obesity & metabolism. 2022 May 30; 24 (9) 1741-1752
Dickerson MT, Dadi PK, Zaborska KE, Nakhe AY, Schaub CM, Dobson JR, Wright NM, Lynch JC, Scott CF, Robinson LD, Jacobson DA, G protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na/K ATPase activation Nature communications. 2022 Oct 29; 13 (1) 6461
Rahim M, Nakhe AY, Banerjee DR, Overway EM, Bosma KJ, Rosch JC, Oeser JK, Wang B, Lippmann ES, Jacobson DA, O'Brien RM, Young JD, Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells The Journal of biological chemistry. 2022 Feb 15; 298 (4) 101729
Cheung R, Pizza G, Chabosseau P, Rolando D, Tomas A, Burgoyne T, Wu Z, Salowka A, Tapa A, Macklin A, Cao Y, Nguyen-Tu MS, Dickerson MT, Jacobson DA, Marchetti P, Shapiro J, Piemonti L, de Koning E, Leclerc I, Bouzakri K, Sakamoto K, Smith DM, Rutter GA, Martinez-Sanchez A, Glucose-Dependent miR-125b is a Negative Regulator of β-Cell Function Diabetes. 2022 Apr 27;

2021

Mousavy Gharavy SN, Owen BM, Millership SJ, Chabosseau P, Pizza G, Martinez-Sanchez A, Tasoez E, Georgiadou E, Hu M, Fine NHF, Jacobson DA, Dickerson MT, Idevall-Hagren O, Montoya A, Kramer H, Mehta Z, Withers DJ, Ninov N, Gadue PJ, Cardenas-Diaz FL, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Voz M, Rutter GA, Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis Diabetologia. 2021 Jan 25; 64 (4) 850-864
Sanavia T, Huang C, Manduchi E, Xu Y, Dadi PK, Potter LA, Jacobson DA, Di Camillo B, Magnuson MA, Stoeckert CJ, Gu G, Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation Frontiers in cell and developmental biology. 2021 May 04; 9 648791
Kuo T, Du W, Miyachi Y, Dadi PK, Jacobson DA, Segrè D, Accili D, Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function Molecular metabolism. 2021 May 25; 53 101256
Graff SM, Johnson SR, Leo PJ, Dadi PK, Dickerson MT, Nakhe AY, McInerney-Leo AM, Marshall M, Zaborska KE, Schaub CM, Brown MA, Jacobson DA, Duncan EL, A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young JCI insight. 2021 Jul 08; 6 (13)
West JD, Austin ED, Rizzi EM, Yan L, Tanjore H, Crabtree AL, Moore CS, Muthian G, Carrier EJ, Jacobson DA, Hamid R, Kendall PL, Majka S, Rathinasabapathy A, KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models International journal of molecular sciences. 2021 May 09; 22 (9)
Altman MK, Schaub CM, Dadi PK, Dickerson MT, Zaborska KE, Nakhe AY, Graff SM, Galletta TJ, Amarnath G, Thorson AS, Gu G, Jacobson DA, TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation Development (Cambridge, England). 2021 Aug 16; 148 (16)
Dickerson MT, Jacobson DA, Channeling β-cell Maturity: KATP Surface Localization Imparts Glucose Sensing Endocrinology. 2021 162 (11)

2020

Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G, Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response Diabetes. 2020 Apr 03; 69 (6) 1219-1231
Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA, The pore-forming subunit MCU of the mitochondrial Ca uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice Diabetologia. 2020 Apr 29; 63 (7) 1368-1381
Lengyel M, Czirják G, Jacobson DA, Enyedi P, TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons The Journal of biological chemistry. 2020 Jul 07; 295 (35) 12408-12425
Zaborska KE, Dadi PK, Dickerson MT, Nakhe AY, Thorson AS, Schaub CM, Graff SM, Stanley JE, Kondapavuluru RS, Denton JS, Jacobson DA, Lactate activation of α-cell K channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca entry Molecular metabolism. 2020 Jul 28; 42 101056
Dickerson MT, Dadi PK, Butterworth RB, Nakhe AY, Graff SM, Zaborska KE, Schaub CM, Jacobson DA, Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion The Journal of physiology. 2020 Sep 01; 598 (21) 4887-4905
Yang B, Maddison LA, Zaborska KE, Dai C, Yin L, Tang Z, Zang L, Jacobson DA, Powers AC, Chen W, RIPK3-mediated inflammation is a conserved β cell response to ER stress Science advances. 2020 Dec 18; 6 (51)
Perfitt TL, Wang X, Dickerson MT, Stephenson JR, Nakagawa T, Jacobson DA, Colbran RJ, Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 Feb 03;

2019

Kharade SV, Sanchez-Andres JV, Fulton MG, Shelton EL, Blobaum AL, Engers DW, Hofmann CS, Dadi PK, Lantier L, Jacobson DA, Lindsley CW, Denton JS, Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063 The Journal of pharmacology and experimental therapeutics. 2019 Jun 14; 370 (3) 350-359
Jacobson DA, Shyng SL, Ion Channels of the Islets in Type 2 Diabetes Journal of molecular biology. 2019 Aug 30;
Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G, Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity Developmental cell. 2019 Jan 7; 48 (1) 49-63.e7
Dickerson MT, Dadi PK, Altman MK, Verlage KR, Thorson AS, Jordan KL, Vierra NC, Amarnath G, Jacobson DA, Glucose-mediated inhibition of calcium-activated potassium channels limits alpha-cell calcium influx and glucagon secretion American journal of physiology. Endocrinology and metabolism. 2019 Jan 29;

2018

Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NHF, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F, Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes JCI insight. 2018 Jun 21; 3 (12)
Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Kadare KA, Altman MK, Milian SC, Jacobson DA, TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin… Molecular metabolism. 2018 Jan 31;
Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC, Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI insight. 2018 Apr 19; 3 (8)
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G, Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin … Developmental cell. 2018 Apr 12;
Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA, Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β… Scientific reports. 2018 Jan 18; 8 (1) 1158
Vierra NC, Dickerson MT, Philipson LH, Jacobson DA, Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca2+ Influx to Assess the R… Methods in molecular biology (Clifton, N.J.). 2018 1684 73-84

2017

Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ, Glucocorticoids Reprogram Beta Cell Signaling to Preserve Insulin Secretion. Diabetes. 2017 Dec 4;
Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA, TALK-1 channels control β cell endoplasmic reticulum Ca(2+) homeostasis. Science signaling. 2017 Sep 19; 10 (497)
Wang X, Marks CR, Perfitt TL, Nakagawa T, Lee A, Jacobson DA, Colbran RJ, A novel mechanism for Ca(2+)/calmodulin-dependent protein kinase II targeting to L-type Ca(2+) chann… The Journal of biological chemistry. 2017 Sep 15;
Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J, β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and patho… Nature communications. 2017 Feb 1; 8 14295
Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA, Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells. PloS one. 2017 12 (4) e0175069
Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA, Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated … Diabetes. 2017 May 26;

2016

Dadi PK, Vierra NC, Days EL, Dickerson M, Vinson PN, Weaver CD, Jacobson DA, Selective small molecule activators of TREK-2 channels stimulate DRG c-fiber nociceptor K2P currents… ACS chemical neuroscience. 2016 Nov 2;
Navarro G, Xu W, Jacobson DA, Wicksteed B, Allard C, Zhang G, De Gendt K, Kim SH, Wu H, Zhang H, Verhoeven G, Katzenellenbogen JA, Mauvais-Jarvis F, Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Ma… Cell metabolism. 2016 Apr 26;
Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM, G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology. 2016 Jun 14; en20161245

2015

Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA, The type-2 diabetes-associated K+ channel TALK-1 modulates beta-cell electrical excitability, 2nd-ph… Diabetes. 2015 Aug 3;
Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M, Activation of FoxM1 revitalizes the replicative potential of aged β -cells in male mice and enhance… Diabetes. 2015 Aug 6;
Dadi PK, Luo B, Vierra NC, Jacobson DA, TASK-1 potassium channels limit pancreatic alpha-cell calcium influx and glucagon secretion. Molecular endocrinology (Baltimore, Md.). 2015 Apr 7; me20141321

2014

Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD, ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to p… Molecular metabolism. 2014 Aug 3 (5) 544-53
Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA, Inhibition of Pancreatic β-Cell Ca2+/Calmodulin-dependent Protein Kinase II Reduces Glucose-stimula… The Journal of biological chemistry. 2014 May 2; 289 (18) 12435-45
Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS, Direct Activation of β-Cell KATP Channels with a Novel Xanthine Derivative. Molecular pharmacology. 2014 Jun 85 (6) 858-65
Egnatchik A., Leamy K., Jacobson A., Shiota, Young D., ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to p… molecular metabolism. 2014 May 23; 4 (4)
Dadi PK, Vierra NC, Jacobson DA, Pancreatic beta-cell specific ablation of TASK-1 channels augments glucose-stimulated calcium entry … Endocrinology. 2014 Jun 16; en20132051

2013

Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B, β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasin… Diabetes. 2013 May 62 (5) 1527-36
Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM, G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes. 2013 May 62 (5) 1547-56
Baerenwald DA, Bonnefond A, Bouatia-Naji N, Flemming BP, Umunakwe OC, Oeser JK, Pound LD, Conley NL, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O, , Dadi PK, Jacobson DA, Froguel P, O'Brien RM, Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fastin… Diabetologia. 2013 Jun 56 (6) 1306-16

2012

Denton JS, Jacobson DA, Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis. Trends in endocrinology and metabolism: TEM. 2012 Jan 23 (1) 41-8
Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM, The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influen… PloS one. 2012 7 (7) e40972

2010

Jacobson DA, Mendez F, Thompson M, Torres J, Cochet O, Philipson LH, Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and c… The Journal of physiology. 2010 Sep 15; 588 (Pt 18) 3525-37

2009

Jacobson DA, Wicksteed BL, Philipson LH, The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing. Diabetes. 2009 Feb 58 (2) 304-6
Fridlyand LE, Jacobson DA, Kuznetsov A, Philipson LH, A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. Biophysical journal. 2009 Apr 22; 96 (8) 3126-39
Deriy LV, Gomez EA, Jacobson DA, Wang X, Hopson JA, Liu XY, Zhang G, Bindokas VP, Philipson LH, Nelson DJ, The granular chloride channel ClC-3 is permissive for insulin secretion. Cell metabolism. 2009 Oct 10 (4) 316-23

2008

Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J, Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta i… American journal of physiology. Endocrinology and metabolism. 2008 Feb 294 (2) E217-29

2007

Jacobson DA, Kuznetsov A, Lopez JP, Kash S, Ammälä CE, Philipson LH, Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell metabolism. 2007 Sep 6 (3) 229-35
Jacobson DA, Philipson LH, Action potentials and insulin secretion: new insights into the role of Kv channels. Diabetes, obesity & metabolism. 2007 Nov 9 Suppl 2 89-98
Jacobson DA, Philipson LH, TRP channels of the pancreatic beta cell. Handbook of experimental pharmacology. 2007 (179) 409-24
Jacobson DA, Weber CR, Bao S, Turk J, Philipson LH, Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyun… The Journal of biological chemistry. 2007 Mar 9; 282 (10) 7442-9

2006

Jacobson DA, Cho J, Landa LR, Tamarina NA, Roe MW, Buxbaum JD, Philipson LH, Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression. American journal of physiology. Endocrinology and metabolism. 2006 Sep 291 (3) E587-95

Unknown

Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R, Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males Cell reports. Unknown 37 (2) 109813
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC, Dapagliflozin Does Not Directly Affect Human α or β Cells Endocrinology. Unknown 161 (8)
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