Parkinsonism & related disorders
AUTHORS
Guigoni
CC ,
Aubert
I I ,
Li
Q Q ,
Gurevich
VV V V ,
Benovic
JL J L ,
Ferry
S S ,
Mach
U U ,
Stark
H H ,
Leriche
L L ,
Håkansson
K K ,
Bioulac
BH Bernard H ,
Gross
CE Christian E ,
Sokoloff
P Pierre ,
Fisone
G Gilberto ,
Gurevich
EV E V ,
Bloch
B Bertrand ,
Bezard
E Erwan .
Parkinsonism & related disorders. 2005 6 ; 11 Suppl 1().
S25-9
- PMID: 15885624[PubMed].
ABSTRACT
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson’s disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases.