Regulation of Calcium Channels

Posted by Digital Strategies (Div of Comm) on Monday, June 4, 2018 in Uncategorized.

Calcium entry via voltage-gated calcium channels drives numerous neuronal responses, including gene transcription and endocannabinoid synthesis. CaMKII is a key mediator of these downstream signals, but CaMKII also serves as a feedback regulator of several different types of calcium channel, generally facilitating calcium entry. We found that CaMKII directly interacts with and phosphorylates multiple types of the pore-forming alpha1 and the beta regulatory subunits in the calcium channel complexes. Ongoing studies are investigating the roles of individual phosphorylation sites and specific interactions in both feedback modulation of the channels and in downstream calcium signaling.