{"id":29,"date":"2022-07-30T23:26:12","date_gmt":"2022-07-30T23:26:12","guid":{"rendered":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/?page_id=29"},"modified":"2022-07-30T23:26:12","modified_gmt":"2022-07-30T23:26:12","slug":"recent-publications","status":"publish","type":"page","link":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/recent-publications\/","title":{"rendered":"Recent Publications"},"content":{"rendered":"

Recent Publications <\/strong>(last 10 years)<\/h1>\n

\u00a0<\/strong><\/p>\n

2022<\/strong><\/h3>\n

 <\/p>\n

V.M. Ngwa, D.N. Edwards, Y. Hwang C. Yan, A. Richmond, D.M. Brantley-Sieders, and J. Chen<\/strong> (2022)<\/p>\n

Loss of vascular endothelial glutaminase inhibits tumor growth and metastasis, and increases sensitivity to chemotherapy.\u00a0 Cancer Res<\/em> Commun <\/em>(In press)<\/p>\n

Wang-Bishop, L, Baljon, J.J., Wehbe, M., Madden, M.Z., Hanna, A., Becker, K.W., Garland, K.M., Wen, X., Shae, D., Edwards, D., Beckermann, K.E., Wolf, M., Delapp, R., Christov, P., Balko, J.M., Rathmell, J.C., Chen, J.<\/strong>, Rathmell, W.K., and Wilson, J.T.. <\/sup>(2022)<\/p>\n

STING-Activating Nanoparticles Reprogram the Vascular-Immune Interface to Amplify Responses to Cancer Immunotherapies.\u00a0 Science Immunology <\/em>(In revision).<\/p>\n

2021<\/strong><\/h3>\n

Chen J<\/strong>.\u00a0HIF1a or HIF2a: Enhancing CD8+<\/sup>\u00a0T-cell Fitness for Antitumor Immunity<\/a>.\u00a0Cancer Immunol Res<\/u>. 2021 Apr; 9(4): 364. PMID: 34003767, PII: 9\/4\/364, DOI: 10.1158\/2326-6066.CIR-21-0114, ISSN: 2326-6074.<\/p>\n

Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR,\u00a0Chen J<\/strong>.\u00a0Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer<\/a>.\u00a0J Clin Invest<\/u>. 2021 Feb 2\/15\/2021; 131(4): PMID: 33320840, PMCID: PMC7880417, PII: 140100, DOI: 10.1172\/JCI140100, ISSN: 1558-8238.<\/p>\n

 <\/p>\n

2020<\/strong><\/h3>\n

Kim LC, Rhee CH,\u00a0Chen J<\/strong>.\u00a0RICTOR<\/em>\u00a0Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1<\/a>.\u00a0Mol Cancer Res [print-electronic]<\/u>. 2020 Aug 8\/14\/2020; PMID: 32801163, PII: 1541-7786.MCR-20-0262, DOI: 10.1158\/1541-7786.MCR-20-0262, ISSN: 1557-3125.<\/p>\n

Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M,\u00a0Chen J<\/strong>.\u00a0Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity<\/a>.\u00a0JCI Insight<\/u>. 2020 Aug 8\/6\/2020; 5(15): PMID: 32759497, PMCID: PMC7455083, PII: 139237, DOI: 10.1172\/jci.insight.139237, ISSN: 2379-3708.<\/p>\n

Song W, Kim LC, Han W, Hou Y, Edwards DN, Wang S, Blackwell TS, Cheng F, Brantley-Sieders DM,\u00a0Chen J<\/strong>.\u00a0Phosphorylation of PLC\u00bf1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer<\/a>.\u00a0Mol Cancer Res [print-electronic]<\/u>. 2020 Aug 8\/4\/2020; PMID: 32753469, PII: 1541-7786.MCR-20-0075, DOI: 10.1158\/1541-7786.MCR-20-0075, ISSN: 1557-3125.<\/p>\n

Shiuan E, Inala A, Wang S, Song W, Youngblood V,\u00a0Chen J<\/strong>, Brantley-Sieders DM.\u00a0Host deficiency in ephrin-A1 inhibits breast cancer metastasis<\/a>.\u00a0F1000Res<\/u>. 2020; 9: 217. PMID: 32399207, PMCID: PMC7194498.2, DOI: 10.12688\/f1000research.22689.2, ISSN: 2046-1402.<\/p>\n

Shiuan EF, Song W, Wang S, Brantley-Sieders DM, and Chen J.<\/strong>\u00a0 (2020) Tumor-specific EphA2 receptor tyrosine kinase inhibits anti-tumor immunity by recruiting suppressive myeloid populations in in NSCLC. BopRxiv doi: https:\/\/doi.org\/10.1101\/2020.05.08.084830<\/p>\n

Yang, G., Song, W., Postoak, J.L., Chen, J.<\/strong>, Martinez, J., Zhang, J., Wu, L., Van Kaer, L.\u00a0 (2020) Autophagy-related protein Vps34 controls T cell metabolism and function.\u00a0 Autophagy<\/em> 16:1-12.<\/p>\n

<\/h3>\n

2019<\/strong><\/h3>\n

Ngwa VM, Edwards DN, Philip M,\u00a0Chen J<\/strong>.\u00a0Microenvironmental Metabolism Regulates Antitumor Immunity<\/a>.\u00a0Cancer Res [print-electronic]<\/u>. 2019 Aug 8\/15\/2019; 79(16): 4003-8. PMID: 31362930, PMCID: PMC6697577, PII: 0008-5472.CAN-19-0617, DOI: 10.1158\/0008-5472.CAN-19-0617, ISSN: 1538-7445.<\/p>\n

Hwang Y, Kim LC, Song W, Edwards DN, Cook RS,\u00a0Chen J<\/strong>.\u00a0Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth\u00a0In Vivo<\/em><\/a>.\u00a0Cancer Res [print-electronic]<\/u>. 2019 Jul 7\/1\/2019; 79(13): 3178-84. PMID: 31085701, PMCID: PMC6606357, PII: 0008-5472.CAN-18-3658, DOI: 10.1158\/0008-5472.CAN-18-3658, ISSN: 1538-7445.<\/p>\n

2018<\/strong><\/h3>\n

Raybuck AL, Cho SH, Li J, Rogers MC, Lee K, Williams CL, Shlomchik M, Thomas JW,\u00a0Chen J<\/strong>, Williams JV, Boothby MR.\u00a0B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity<\/a>.\u00a0J. Immunol [print-electronic]<\/u>. 2018 Apr 4\/15\/2018; 200(8): 2627-39. PMID: 29531165, PMCID: PMC5893413, PII: jimmunol.1701321, DOI: 10.4049\/jimmunol.1701321, ISSN: 1550-6606.<\/p>\n

2017<\/strong><\/h3>\n

Edwards DN, Ngwa VM, Wang S, Shiuan E, Brantley-Sieders DM, Kim LC, Reynolds AB,\u00a0Chen J<\/strong>.\u00a0The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ<\/a>.\u00a0Sci Signal<\/u>. 2017 Dec 12\/5\/2017; 10(508): PMID: 29208682, PMCID: PMC5819349, PII: 10\/508\/eaan4667, DOI: 10.1126\/scisignal.aan4667, ISSN: 1937-9145.<\/p>\n

Song W, Hwang Y, Youngblood VM, Cook RS, Balko JM,\u00a0Chen J<\/strong>, Brantley-Sieders DM.\u00a0Targeting EphA2 impairs cell cycle progression and growth of basal-like\/triple-negative breast cancers<\/a>.\u00a0Oncogene [print-electronic]<\/u>. 2017 Oct 10\/5\/2017; 36(40): 5620-30. PMID: 28581527, PMCID: PMC5629103, PII: onc2017170, DOI: 10.1038\/onc.2017.170, ISSN: 1476-5594.<\/p>\n

Finney AC, Funk SD, Green JM, Yurdagul A, Rana MA, Pistorius R, Henry M, Yurochko A, Pattillo CB, Traylor JG,\u00a0Chen J<\/strong>, Woolard MD, Kevil CG, Orr AW.\u00a0EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis<\/a>.\u00a0Circulation [print-electronic]<\/u>. 2017 Aug 8\/8\/2017; 136(6): 566-82. PMID: 28487392, PMCID: PMC5548618, PII: CIRCULATIONAHA.116.026644, DOI: 10.1161\/CIRCULATIONAHA.116.026644, ISSN: 1524-4539.<\/p>\n

Kim LC, Cook RS,\u00a0Chen J<\/strong>.\u00a0MTORC1 and mTORC2 in cancer and the tumor microenvironment<\/a>.\u00a0Oncogene [print-electronic]<\/u>. 2017 Apr 4\/20\/2017; 36(16): 2191-201. PMID: 27748764, PMCID: PMC5393956, PII: onc2016363, DOI: 10.1038\/onc.2016.363, ISSN: 1476-5594.<\/p>\n

2016<\/strong><\/h3>\n

Shiuan E,\u00a0Chen J<\/strong>.\u00a0Eph Receptor Tyrosine Kinases in Tumor Immunity<\/a>.\u00a0Cancer Res [print-electronic]<\/u>. 2016 Nov 11\/15\/2016; 76(22): 6452-7. PMID: 27811149, PMCID: PMC5290221, PII: 0008-5472.CAN-16-1521, DOI: 10.1158\/0008-5472.CAN-16-1521, ISSN: 1538-7445.<\/p>\n

Youngblood VM, Kim LC, Edwards DN, Hwang Y, Santapuram PR, Stirdivant SM, Lu P, Ye F, Brantley-Sieders DM,\u00a0Chen J<\/strong>.\u00a0The Ephrin-A1\/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer<\/a>.\u00a0Cancer Res [print-electronic]<\/u>. 2016 Apr 4\/1\/2016; 76(7): 1825-36. PMID: 26833123, PMCID: PMC4873477, PII: 0008-5472.CAN-15-0847, DOI: 10.1158\/0008-5472.CAN-15-0847, ISSN: 1538-7445.<\/p>\n

Amato KR, Wang S, Tan L, Hastings AK, Song W, Lovly CM, Meador CB, Ye F, Lu P, Balko JM, Colvin DC, Cates JM, Pao W, Gray NS,\u00a0Chen J<\/strong>.\u00a0EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer<\/a>.\u00a0Cancer Res [print-electronic]<\/u>. 2016 Jan 1\/15\/2016; 76(2): 305-18. PMID: 26744526, PMCID: PMC4715957, PII: 0008-5472.CAN-15-0717, DOI: 10.1158\/0008-5472.CAN-15-0717, ISSN: 1538-7445.<\/p>\n

Takahashi K, Sumarriva K, Kim R, Jiang R, Brantley-Sieders DM,\u00a0Chen J<\/strong>, Mernaugh RL, Takahashi T.\u00a0Determination of the CD148-Interacting Region in Thrombospondin-1<\/a>.\u00a0PLoS ONE<\/u>. 2016; 11(5): e0154916. PMID: 27149518, PMCID: PMC4858292, PII: PONE-D-15-55087, DOI: 10.1371\/journal.pone.0154916, ISSN: 1932-6203.<\/p>\n

Simonik EA, Cai Y, Kimmelshue KN, Brantley-Sieders DM, Loomans HA, Andl CD, Westlake GM, Youngblood VM,\u00a0Chen J<\/strong>, Yarbrough WG, Brown BT, Nagarajan L, Brandt SJ.\u00a0LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer)<\/a>.\u00a0PLoS ONE<\/u>. 2016; 11(10): e0164804. PMID: 27780223, PMCID: PMC5079595, PII: PONE-D-16-16733, DOI: 10.1371\/journal.pone.0164804, ISSN: 1932-6203.<\/p>\n

2015<\/strong><\/h3>\n

Wang S, Amato KR, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders DM,\u00a0Chen J<\/strong>.\u00a0Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways<\/a>.\u00a0Mol. Cell. Biol [print-electronic]<\/u>. 2015 Apr; 35(7): 1299-313. PMID: 25582201, PMCID: PMC4355541, PII: MCB.00306-14, DOI: 10.1128\/MCB.00306-14, ISSN: 1098-5549.<\/p>\n

Youngblood V, Wang S, Song W, Walter D, Hwang Y,\u00a0Chen J<\/strong>, Brantley-Sieders DM.\u00a0Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium<\/a>.\u00a0Mol. Cancer Res [print-electronic]<\/u>. 2015 Mar; 13(3): 524-37. PMID: 25504371, PMCID: PMC4416411, PII: 1541-7786.MCR-14-0142, DOI: 10.1158\/1541-7786.MCR-14-0142, ISSN: 1557-3125.<\/p>\n

Chen J<\/strong>, Song W, Amato K.\u00a0Eph receptor tyrosine kinases in cancer stem cells<\/a>.\u00a0Cytokine Growth Factor Rev [print-electronic]<\/u>. 2015 Feb; 26(1): 1-6. PMID: 24933439, PMCID: PMC4234705, PII: S1359-6101(14)00043-4, DOI: 10.1016\/j.cytogfr.2014.05.001, ISSN: 1879-0305.<\/p>\n

2014<\/strong><\/h3>\n

McCormack DR, Walsh AJ, Sit W, Arteaga CL,\u00a0Chen J<\/strong>, Cook RS, Skala MC.\u00a0In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts<\/a>.\u00a0Biomed Opt Express<\/u>. 2014 Jul 7\/1\/2014; 5(7): 2247-61. PMID: 25071962, PMCID: PMC4102362, PII: 210394, DOI: 10.1364\/BOE.5.002247, ISSN: 2156-7085.<\/p>\n

Song W, Ma Y, Wang J, Brantley-Sieders D,\u00a0Chen J<\/strong>.\u00a0JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer<\/a>.\u00a0Cancer Res [print-electronic]<\/u>. 2014 May 5\/1\/2014; 74(9): 2444-54. PMID: 24607842, PMCID: PMC4008716, PII: 0008-5472.CAN-13-2136, DOI: 10.1158\/0008-5472.CAN-13-2136, ISSN: 1538-7445.<\/p>\n

Amato KR, Wang S, Hastings AK, Youngblood VM, Santapuram PR, Chen H, Cates JM, Colvin DC, Ye F, Brantley-Sieders DM, Cook RS, Tan L, Gray NS,\u00a0Chen J<\/strong>.\u00a0Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC<\/a>.\u00a0J. Clin. Invest [print-electronic]<\/u>. 2014 May; 124(5): 2037-49. PMID: 24713656, PMCID: PMC4001547, PII: 72522, DOI: 10.1172\/JCI72522, ISSN: 1558-8238.<\/p>\n

Takahashi K, Matafonov A, Sumarriva K, Ito H, Lauhan C, Zemel D, Tsuboi N,\u00a0Chen J<\/strong>, Reynolds A, Takahashi T.\u00a0CD148 tyrosine phosphatase promotes cadherin cell adhesion<\/a>.\u00a0PLoS ONE<\/u>. 2014; 9(11): e112753. PMID: 25386896, PMCID: PMC4227875, PII: PONE-D-14-33624, DOI: 10.1371\/journal.pone.0112753, ISSN: 1932-6203.<\/p>\n

2013<\/strong><\/h3>\n

Boissier P,\u00a0Chen J<\/strong>, Huynh-Do U.\u00a0EphA2 signaling following endocytosis: role of Tiam1<\/a>.\u00a0Traffic [print-electronic]<\/u>. 2013 Dec; 14(12): 1255-71. PMID: 24112471, PMCID: PMC3859973, DOI: 10.1111\/tra.12123, ISSN: 1600-0854.
\nO\u2019Neal WT, Griffin WF, Dries JL, Kent S, Chen J,<\/strong> Willis MS, Virag, JAI. (2013) Ephrin-Eph signaling as a potential therapeutic target for the treatment of myocardial infarction.\u00a0 Medical Hypotheses<\/em> 80:738-44.<\/p>\n

 <\/p>\n

2012<\/strong><\/h3>\n

Zhuang G, Song W, Amato K, Hwang Y, Lee K, Boothby M, Ye F, Guo Y, Shyr Y, Lin L, Carbone DP, Brantley-Sieders DM,\u00a0Chen J<\/strong>.\u00a0Effects of cancer-associated EPHA3 mutations on lung cancer<\/a>.\u00a0J. Natl. Cancer Inst [print-electronic]<\/u>. 2012 Aug 8\/8\/2012; 104(15): 1182-97. PMID: 22829656, PMCID: PMC3611812, PII: djs297, DOI: 10.1093\/jnci\/djs297, ISSN: 1460-2105.<\/p>\n

Hahn AS, Kaufmann JK, Wies E, Naschberger E, Panteleev-Ivlev J, Schmidt K, Holzer A, Schmidt M,\u00a0Chen J<\/strong>, K\u00f6nig S, Ensser A, Myoung J, Brockmeyer NH, St\u00fcrzl M, Fleckenstein B, Neipel F.\u00a0The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi’s sarcoma\u2013associated herpesvirus<\/a>.\u00a0Nat. Med<\/u>. 2012 Jun; 18(6): 961-6. PMID: 22635007, PMCID: PMC3645317, PII: nm.2805, DOI: 10.1038\/nm.2805, ISSN: 1546-170X.<\/p>\n

Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R,\u00a0Chen J<\/strong>, Volanakis E, Boothby M.\u00a0Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia<\/a>.\u00a0J. Exp. Med [print-electronic]<\/u>. 2012 Apr 4\/9\/2012; 209(4): 713-28. PMID: 22473959, PMCID: PMC3328370, PII: jem.20111470, DOI: 10.1084\/jem.20111470, ISSN: 1540-9538.<\/p>\n

Funk SD, Yurdagul A, Albert P, Traylor JG, Jin L,\u00a0Chen J<\/strong>, Orr AW.\u00a0EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis<\/a>.\u00a0Arterioscler. Thromb. Vasc. Biol [print-electronic]<\/u>. 2012 Mar; 32(3): 686-95. PMID: 22247258, PMCID: PMC3325141, PII: ATVBAHA.111.242792, DOI: 10.1161\/ATVBAHA.111.242792, ISSN: 1524-4636.<\/p>\n

Chen J<\/strong>.\u00a0Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases<\/a>.\u00a0Adv. Cancer Res<\/u>. 2012; 114: 1-20. PMID: 22588054, PMCID: PMC3626259, PII: B978-0-12-386503-8.00001-6, DOI: 10.1016\/B978-0-12-386503-8.00001-6, ISSN: 0065-230X.<\/p>\n

Rao M, Song W, Jiang A, Shyr Y, Lev S, Greenstein D, Brantley-Sieders D,\u00a0Chen J<\/strong>.\u00a0VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity<\/a>.\u00a0PLoS ONE [print-electronic]<\/u>. 2012; 7(10): e46281. PMID: 23049696, PMCID: PMC3462209, PII: PONE-D-12-16139, DOI: 10.1371\/journal.pone.0046281, ISSN: 1932-6203.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Recent Publications (last 10 years) \u00a0 2022   V.M. Ngwa, D.N. Edwards, Y. Hwang C. Yan, A. Richmond, D.M. Brantley-Sieders, and J. Chen (2022) Loss of vascular endothelial glutaminase inhibits tumor growth and metastasis, and increases sensitivity to chemotherapy.\u00a0 Cancer Res Commun (In press) Wang-Bishop, L, Baljon, J.J., Wehbe, M., Madden, M.Z., Hanna, A., Becker,…<\/p>\n","protected":false},"author":363,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"class_list":["post-29","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/pages\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/users\/363"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/comments?post=29"}],"version-history":[{"count":4,"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/pages\/29\/revisions"}],"predecessor-version":[{"id":33,"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/pages\/29\/revisions\/33"}],"wp:attachment":[{"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/media?parent=29"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lab.dev.vanderbilt.edu\/chen-lab\/wp-json\/wp\/v2\/tags?post=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}