Deprecated: Optional parameter $limit declared before required parameter $showlink is implicitly treated as a required parameter in /var/www/m_lab.dev.vanderbilt.edu/wp-content/plugins/wp-pubmed-reflist/class.wpPubMedRefList.php on line 27

Deprecated: Optional parameter $subset declared before required parameter $showlink is implicitly treated as a required parameter in /var/www/m_lab.dev.vanderbilt.edu/wp-content/plugins/wp-pubmed-reflist/class.wpPubMedRefList.php on line 27

Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the sgg domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/m_lab.dev.vanderbilt.edu/wp-includes/functions.php on line 6114
The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans. | Broadie Laboratory | Vanderbilt University Skip to main content

The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans.


AUTHORS

Richmond JEJanet E , Broadie KS Kendal S . Current opinion in neurobiology. 2002 10 ; 12(5). 499-507

ABSTRACT

Advances in the study of Drosophila melanogaster and Caenorhabditis elegans have provided key insights into the processes of neurotransmission and neuromodulation. Work in the past year has revealed that Unc-13 and Rab3a-interacting molecule regulate the conformational state of syntaxin to prime synaptic vesicle fusion. Analyses of synaptotagmin support its role as a putative calcium sensor triggering vesicular fusion and highlight the possible role of SNARE complex oligomerization in the fusion mechanism. Characterization of endophilin mutants demonstrates that kiss-and-run endocytosis is a major component of synaptic vesicle recycling. In neuromodulation, dcaps mutants provide the first genetic insight into possible roles of the CAPS protein in mediating dense core vesicle fusion and modulating synaptic vesicle fusion.


Advances in the study of Drosophila melanogaster and Caenorhabditis elegans have provided key insights into the processes of neurotransmission and neuromodulation. Work in the past year has revealed that Unc-13 and Rab3a-interacting molecule regulate the conformational state of syntaxin to prime synaptic vesicle fusion. Analyses of synaptotagmin support its role as a putative calcium sensor triggering vesicular fusion and highlight the possible role of SNARE complex oligomerization in the fusion mechanism. Characterization of endophilin mutants demonstrates that kiss-and-run endocytosis is a major component of synaptic vesicle recycling. In neuromodulation, dcaps mutants provide the first genetic insight into possible roles of the CAPS protein in mediating dense core vesicle fusion and modulating synaptic vesicle fusion.


Tags:

Leave a Response


Warning: Undefined variable $user_ID in /var/www/m_lab.dev.vanderbilt.edu/wp-content/themes/ANCHORDOWN-Vanderbilt/comments.php on line 62